441-CHF only

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Author:
jgiantess
ID:
124289
Filename:
441-CHF only
Updated:
2011-12-18 03:39:45
Tags:
drugs
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Description:
pharmacology
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  1. milrinone
    • positive inotropic: phosphodiesterase inhibitor: used for refractory CHF. short term therapy.
    • Increases cardiac cAMP -> activation of protein kinase allows phosphorylation of cellular proteins (i.e. slow Ca2+ channel) --> increase Ca2+ influx, more Ca in SR --> increased CO.
    • In vascular SM, cAMP promotes direct relaxation.
  2. dobutamine
    positive inotropic: B-adrenoceptor agonist -> increase cAMP --------> increase cardiac output.
  3. Nesiritide
    • synthetic brain natriuretic peptide (===ANP)
    • increases cGMP in smooth muscle cells -> decrease Ca, decrease force of contraction, leads to SM relaxation.
    • Reduces venous and arteriolar tone --> powerful vasodilator.
    • Also causes diuresis.

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