441-preMT

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Author:
jgiantess
ID:
124292
Filename:
441-preMT
Updated:
2011-12-18 03:50:29
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drugs
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Description:
pharmacology
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  1. insulin lispro
    Humalog, rapid-acting
  2. insulin aspart
    Novorapid, rapid-acting
  3. insulin glulisine
    Apidra, rapid-acting
  4. humulin-R
    regular insulin
  5. novolin ge toronto
    regular insulin
  6. NPH insulin
    • neutral protamine hagedorn
    • humulin-N, Novolin ge NPH
  7. insulin glargine
    Lantus, long-acting
  8. insulin detemir
    Levemir, long-acting
  9. sulfonylureas
    glyburide, glipizide, glimepiride
  10. meglitinides
    repaglinide, nateglinide
  11. biguanides
    metformin
  12. thiazolidinediones
    pioglitazone, rosiglitazone
  13. alpha-glucosidase inhibitor
    acarbose
  14. incretin agent
    sitagliptin, exenatide, liraglutide
  15. HMG-CoA reductase inhibitors
    prava, lova, atorva, simva, fluva, rosuvastatin
  16. cholestyramine
    bile acid sequestrants (resins)
  17. colestipol
    bile acid sequestrants (resins)
  18. ezetimibe
    cholesterol absorption inhibitor
  19. niacin
    nicotinic acid, TGL inhibitor
  20. fibrates
    gemfibrozil, fenofibrate, bezafibrate - PPAR-alpha stimulants
  21. orlistat
    Xenical, gastric/pancreatic lipase inhibitor
  22. 17-beta estradiol
    E2, most potent natural estrogen, made in ovaries
  23. estrone
    E1, made in tissues, liver, placenta (during pregs), adipose tissue in postmen
  24. estriol
    E3, metabolite of both E1 and E2, made in liver and placenta
  25. tamoxifen
    SERM, 1st line tx of BC in premen, also in px. risk of endometrial cancer
  26. raloxifene
    • SERM, px only for postmenopause.
    • Osteoporosis: anti-resorptive (anti-catabolic).
    • increase BMD in postmen, but less than E or alendronate.
    • 50% RR of vertebral fx, no effect on non-vert or hip.
    • Also decreases risk of breast cancer.
    • May aggravate vasomotor symptoms (due to selective anti-E effect).
    • Increase risk of VTE (similar to HRT).
  27. clomiphene
    SERM-like, antiestrogenic (blocks - feedback of E at hypo and pit, increases gonadotropins), tx anovulatory infertility
  28. anastrazole
    aromatase inhibitor
  29. letrozole
    aromatase inhibitor
  30. ezemestane
    aromatase inhibitor
  31. fulvestrant
    anti-estrogen; bids to ER and competitively inhibits E binding, causes receptor degradation. for metastatic breast cancer
  32. norethindrone
    1st gen progestin, potency 1, weak androgenic.
  33. levonorgestrel
    2nd gen progestin, potency 10-20, most androgenic activity
  34. desogestrel
    3rd gen progestin, potency 10-20, lower androgenic activity than levonorgestrel
  35. drospirenone
    progestin component, analogue of spironolactone; potency 2, no androgenicity, but slight anti-mineralocorticoid (blocks activity of aldosterone)
  36. mifepristone
    • anti-progestin; competitive PR inhibitor, blocks ovulation if in F, causes menses if in L.
    • abortion pill
  37. ulipristal acetate
    • SPRM: binds PR and partial agonist activity
    • anti-ovulatory (inhibits LH release and ovulation)decreases endometrial thickness and impairs implantation
    • ECP (===planB)
  38. ovral
    norgestrel + EE
  39. Evra
    norelgestromin + EE
  40. Mirena
    levonorgestrel
  41. Nuvaring
    etonorgestrel + EE
  42. gonadorelin
    • synthetic GnRH
    • pulsatile: profertility (LH release)
    • continuous: suppress gonadotropin secretion (mostly the agonists though)
  43. buserelin
    GnRH agonist; profertility (pulses) OR suppression of LH/FSH in advanced prostate cancer
  44. nafarelin
    GnRH agonist; profertility (pulses) OR suppression of LH/FSH in endometriosis (continuous)
  45. leuprolide
    GnRH agonist; profertility (pulses) OR suppression of LH/FSH in advanced prostate cancer
  46. ganirelix
    GnRH antag; inhibition of LH/FSH secretion without agonist phase; for in vitro fert or advanced prostate cancer
  47. cetrorelix
    GnRH antag; inhibition of LH/FSH secretion without agonist phase; for in vitro fert or advanced prostate cancer
  48. danazol
    • synthetic weak androgen
    • decrease GnRH and LH/FSH secretion; decrease sex steroid secretion by ovaries
    • tx endometriosis
  49. testosterone undecanoate
    testosterone ester, PO, absorbed into lymph, bypass hepatic breakdown
  50. testosterone cypionate, enanthate
    test. esters; FFA esterified at 17-beta-OH position
  51. stanozolol
    17-alpha-alkylated androgens, anabolic steroid - hepatotoxicity
  52. flutamide
    • pure anti-androgen
    • blocks receptors at target, hypo, and pit; but also blocks - feedback so testosterone increases
    • for tx advanced prostatic carcinoma
    • may be given with GnRH agonist to decrease testosterone
  53. bicalutamide
    • pure anti-androgen
    • blocks receptors at target, hypo, and pit; but also blocks - feedback so testosterone increases
    • for tx advanced prostatic carcinoma
    • may be given with GnRH agonist to decrease testosterone
  54. nilutamide
    • pure anti-androgen
    • blocks receptors at target, but also at hypo, and pit: blocks - feedback so testosterone increases
    • for tx advanced prostatic carcinoma
    • may be given with GnRH agonist to decrease testosterone
  55. cyproterone acetate
    • androgen antagonist with progesterone activity
    • prog act blocks Gn secretion so no increase in testosterone (maintains - feedback on LH)
    • prostatic carcinoma, in Acne
  56. finasteride
    • Proscar, Propecia
    • 5-alpha-reductase inhibitor: prevents conversion to DHT
    • tx of BPH, androgenetic alopecia, prostate cancer px
  57. dutasteride
    • 5-alpha-reductase inhibitor: prevents conversion to DHT
    • tx of BPH, androgenetic alopecia, prostate cancer px

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