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What is the role of antibodies vs. T-lymphocytes in immune response? (p.1-5)
- Antibodies (Class II antigens) – prevent disease
- o Not MHC restricted
- o B-cells mature in lymphoid tissue and circulate in plasma as mature B-cells
- o Once exposed to antigen, turn into plasma cells and secrete antibodies
- T-lymphocytes (Class I antigens) – help recover from infection
- o Responsible for cellular immunity
- o MHC restrictive
- o Must be exposed to antigens in order to be educated and reactive
Between antibodies and T cells, which ones would be responsible for person’s recovery from most viral infections?
What about prevention of disease process?
Are antibodies able to bind circulating free antigens?
Yes. Antigens bind to FC receptor on antibody.
Are T cells able to bind circulating free antigens?
No. T-cells attack antigen-infected cells to aid recovery.