What class of antidepressant is Bupropion (Wellbutrin)
Atypical Antidepressant/2nd Gen w/ SSRI and SNRI
At high doses, what can venlafaxine induce?
What are the side effects of SNRI?
similar to SSRI, also causes HTN in the case of venlafaxine
What is the active metabolite of venlafaxine?
At low to mid doses, Venlafaxine (effector) blocks _____, and at higher doses, the inhibition of ________ increases.
5HT, NE transporters
Which of the 3 SNRI's is a true SNRI? What does it mean to be a "true" SNRI?
Duloxetine is a true SNRI because it inhibits both 5HT and NE reuptake pumps regardless of dose used. (similar to TCA MOA)
List the SNRI using VOD mnemonic
O-desmethyl venlafaxine (Pristiq)
When can GI discomfort caused by SSRI occur?
Anywhere from @ onset (1-2hr post admin.) or when steady state levels are reached.
What side effects can you exp. Taking SSRI?
Most commonly: GI disturbances (N/V/pain), constipation and diarrhea. GI effects go away with continued use. Also, sexual function is effected: reduced libido, delayed orgasm , and delays premature ejaculation
Do SSRI's have a safer side effect profile compared to MAOI and TCA? And yes, give one reason why MAOI and TCA would be less safe?
Yes, SSRI is safer than MAOI and TCA. MAOI can cause tyramine toxicity (tyramine in lots of foods), and TCA can antagonize many receptors
Besides the Raphe Nucleus, where can you find serotonin?
List the SSRI using this mnemonic:
"SSRI Constantly Force Emotions From People"