Pharm CNS

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Author:
nicstrain
ID:
12667
Filename:
Pharm CNS
Updated:
2010-04-05 22:41:10
Tags:
USMLE
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Description:
CNS Drugs
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  1. "TOM"
    • Short-acting BDZs
    • Triazolam
    • Onazelam
    • Midazolam
  2. Butyrophenone
    Haloperidol & Droperidol
  3. Atypical D4
    Clozapine - Thioridazine - Olanzepine - Risperidone = do not cause EPS
  4. Flumazenil
    BDZ antidote for OD
  5. Methylphenidate
    Tx ADD
  6. Phenytoin
    Causes aplastic anemia / gingival hyperplasia / cleft lip & platelet
  7. Thiopental
    Short acting Barb
  8. Carbamazepine
    • DOC thrgeminal neuralgia
    • Tx lennox gestaut seizures in kids
  9. Atypical D4-r
    Thioridazine; Olamzapine; Clozapine
  10. Pimozide
    Tx for Tourette's
  11. Risperidone
    Good for negative symptoms
  12. Thioridazide
    Most anti-cholinergic neuroleptic
  13. Haloperidol
    Neuroleptic malignant hyperthermia due to chronic D2 block. Give Dantrolene and Bromocriptine
  14. Imirpamine
    Enursis
  15. Clomirpramine
    • Tx OCD
    • See aggressive behavior with use
  16. Trazadone
    Priapism
  17. Bupropion
    Helps quit smoking
  18. SSRI's
    Primarily used for OCD
  19. Fluoxetine
    Good for negative symptoms
  20. Phenelzine
    Irreversible MAOI
  21. Lithium
    • Tx manic phase of Bipolar Disorder
    • Causes goiter by (-) conversion of T4 to T3
    • Nephrogenic diabetes insipidus
    • Low Salt diet will lead to Li toxicity
  22. Alprazolam
    DOC for stage fright
  23. Propranolol
    Social phobia
  24. kapaa-r
    • Spinal analgesia, Euphoria
    • ++ euphoria, ++ sedation
    • Constipation
  25. mu-r
    • Supraspinal analgesia, Dysphoria
    • +respiratory depress, + sedation
  26. Morphine & O2
    Admin is contraindicated to pts on morphine sedation = decreased CO2 sensitivity and O2 administration can stop breathing
  27. Morphine
    Increase ICP = do not give to pt with head trauma
  28. Morphine OD
    • Pinpoint pupil
    • Decreased respiration
    • Coma
  29. Meperidine
    Anesthetic used during labor
  30. Hydromorphane
    mu (+) used in renal failure
  31. Tramadol
    Ambulatory tx for mod to severe pain
  32. Naloxone
    • Tx for opioid OD
    • Reverse respiratory depression
  33. Pentazocine
    Part kappa(+) & part mu(-)
  34. Butorphenol
    Part kappa(+) & part mu(-)
  35. Nalbuphene
    Part kappa(+) & part mu(-)
  36. Decreased GABA
    Decreased seizure focus = Barbs and BDZs
  37. Fast Na Ch
    Decreased electrical activity spread = Phenytoin & Carbomazepine
  38. Methoxyflurane
    can be nephrotoxic, needs low MAC for anesthetic induction
  39. Enflurane
    can cause tonic /clonic seizures
  40. Isoflurane
    can cause bronchospasm
  41. Halothane
    Can cause ventricular extrasystoles & malignant hyperthermia & hepatitis
  42. Nitric Oxide
    No effect on HR, Needs high MAC for anesthetic induction
  43. Thiopental
    Short acting barb
  44. Kentamine
    Dissociative anesthetic
  45. Droperidol
    • Can be used in combo w/ Fentanyl for neuroeptoanalgesic effect
    • Neruoeptic tranquilizer, has mild alpha block
  46. Fentanyl
    • Can be used in combo w/ Droperidol for neuroeptoanalgesic effect
    • Used transdermally for chronic pain
  47. Midazolam
    Pre anesthetic, Induces anmesia
  48. Primidone
    Biotransformed to Phenobarb
  49. C and A Delta Fibers
    First fibers to be blocked with anesthesia
  50. Esters
    • Procaine, Tetracaine, Benzocaine
    • Broken down and make PABA (allergen)
  51. Amides
    • Lidocaine, Mepivacine, Bupivacine, Etidocaine = "i" before "caine" always amide
    • Metabolized in liver
  52. Amphetamine
    DA reuptake (-)r. MAOI. Parkinson's tx
  53. Bromocriptine
    D2(+), used with L-Dopa for "on-off" phenomenon for Parkinson's
  54. Benztropine
    Ant M w/ some DA reuptake (-). Parkinson's tx
  55. Amantidine
    • Decreases DA reuptake
    • can cause livido reticularis = skin mottling
  56. Diphenhydramine
    Tx early Parkinson's Stages
  57. Pergolide
    > effective & longer acting than Bromocriptine
  58. Ethosuzimide
    DOC for absence seizures
  59. Tranylcypromine
    MAOI - antidepressant
  60. SSRI & MAOI
    Fatal combo, especially seen with the used of Paroxetine or Fluoxetine (SSRI) adn Tranylcypromine (MAOI)
  61. Labor Opioids
    Meperidine & Nalbuphine
  62. Desipramine Causes
    Sudden cardiac in children

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