Neurotransmitters

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Author:
catitasilva
ID:
126997
Filename:
Neurotransmitters
Updated:
2012-01-10 14:49:30
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Neurotransmitters
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Neurotransmitters
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  1. Types of neurotransmitters
    • acetylcholine
    • biogenic amines (catecholamines, serotonin)
    • peptides
    • amino acids
  2. Neurotransmitter Actions
    • Excitatory NT - increase Na permeability; depolarize
    • Inhibitory NT - increase Ca & K permeability; hyperpolarize
  3. Types of NT receptors
    • G protein linked receptors: hormone like receptors; cascades (2nd messenger)
    • ex: Adrenergic, dopamine, muscarinic cholinergic, opiate
    • Ligand gated ion channel: fast effects; closed at rest, opens w/NT; excitatory or inhibitory
    • ex: nicotinic cholinergic, GABA, NMDA
  4. Acetylcholine Synthesis
    Acetyl coA + Choline --(choline-acetyl transferase)>>Acetylcholine + CoA-SH
  5. Nicotinic Acetycholine Receptor
    • neuromuscular junction
    • ligand gated ion channel
  6. Action of Acetyl Cholinesterase
    • Ach --(Achesterase)>> Acetyl Enzyme Intermediate + Choline
    • Acetyl Enzyme Intermediate --(H2O) >> Ach-esterase + H+ + acetate
  7. Cholinergic Synapses & inhibitors
    Nicotinic Receptors
    Muscarinic Receptors
    • Nicotinic:
    • ligand gated Na
    • NM junction, autonomic ganglia & brain
    • X - curare

    • Muscarinic:
    • G-protein
    • parasympathetic tissues
    • sweat glands
    • brain
    • X- atropine & scopolamine

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