Basics of Neuropathology

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  1. Name the 4 stains commonly used in CNS tissue sectioning.
    • H&E
    • Cresyl violet/ Luxol Fast Blue
    • Silver Stain
    • Glial-Fibrilary Acidic Protein (GFAP, IHC)
  2. Image Upload
    What stain is this?
    H&E Staining
  3. Image Upload
    What stain is this?
    Cresyl violet/Luxol Fast Blue (CV/LFB)
  4. Image Upload
    What stain is this?
    Silver Stain
  5. Image Upload
    What stain is this?
    anti-Glial Fibrillary Acidic Protien (GFAP)
  6. What are the two main CNS tissue reactions to injury?
    • Cerebral edema
    • Hydrocephalus
  7. List the 6 generalized steps in neuronal apoptosis and necrosis
    Ischemia/Trauma => depleted ATP => loss of membrane potential => increased Glu release, decreased reuptake (excess) => increased activation of Glu receptors => increased Ca2+
  8. List the 4 main causes of neuronal cell death
    • Hypoxia/ischemia (common denominator)
    • Toxins
    • Infectious pathogens
    • Metabolic disorders
  9. List the 4 neuronal reactions to injury
    • Chromatolysis (acute axonal rxn)
    • Red Neuron (ischemic change)
    • Neuronal Atrophy (degeneration)
    • Intraneuronal deposits
  10. Describe chromatolysis and its two major attributes
    • Acute, reversible reaction of the perikaryon to axonal injury
    • 1) perikaryon swells
    • 2) nucleus and Nissl bodies displaced peripherally
  11. Image Upload
    What kind of reaction is shown here?
    Chromatolysis
  12. Describe red neuron reaction and 4 major attributes.
    • Acute injury leading to cell death.
    • 1) cell body shrinkage
    • 2) eosinophilic cytoplasm
    • 3) pyknosis of the nucleus
    • 4) loss of Nissl substance (sometimes)
  13. Image Upload
    What kind of reaction is shown here?
    Red neuron
  14. Name 3 common anatomic locations of acute ischemic brain lesions
    • Hippocampus (CA1,3,5)
    • Neocortex (layers 3 & 5)
    • Purkinje cells (cortex, cerebellum)
  15. What is the major difference in acute and chronic ischemic injury on H&E stain?
    • Acute: triangular-shaped neurons
    • Chronic: corkscrew-shaped neurons
  16. What are 3 eventual outcomes of repeated transient ischemic injury?
    • acidophilic neurons
    • edematous neuropil
    • vascular proliferation
  17. Image Upload
    Is this acute, chronic, or transient ischemia?
    Acute
  18. Image Upload
    Is this acute, chronic, or transient ischemia?
    Chronic
  19. Image Upload
    Is this acute, chronic, or transient ischemia?
    Transient
  20. Image Upload
    What pathologic change is circled in green here?
    Vascular proliferation
  21. Image Upload
    What pathologic change is circled in blue here?
    Acidophilic neurons

Card Set Information

Author:
blakegoodman08
ID:
127001
Filename:
Basics of Neuropathology
Updated:
2012-01-10 20:33:45
Tags:
S4M1 S4 Ross University Med Medical School Neurology Pathology
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Description:
From Dr. Martinez's two Neuropathology lectures; focuses on normal and abnormal cellular CNS features, CNS tissue reactions, and the pathologic results of increased ICP and edema,
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