brand-generic.txt

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HUSOP2014
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127123
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brand-generic.txt
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2012-01-25 16:47:12
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HUSOP Top 100 hospital drugs
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Brand to generic, Class, Typical route of administration (RoA), MOA, Indication
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  1. Lovenox
    • Gen: Enoxaparin Sodium
    • Class: Anticoagulant (LMW-heparin)
    • RoA: IV
    • MOA: Anti-Factor Xa and anti-thrombin (Factor IIa) activity
    • Indication: DVT, PE, MI, Ischemia, (all postop and prohhylaxis)
  2. Aranesp
    • Gen: Darbepoetin Alfa
    • Class: Erythropoietic- Hematopoietic
    • RoA: IV or SC
    • MOA: binds progenitor stem cells stimulating production/differentiation of erthropoiesis
    • Indication: Anemia from Chronic kidney disease and Chemotherapy
  3. Procrit
    • Gen: Epoetin Alfa
    • Class: Erythropoietic- Hematopoietic
    • RoA: IV or SC
    • MOA: bone marrow division/differentiation of committed erythroid progenitors
    • Indication: Anemia from Chronic renal failure, Chemotherapy, or Surgical procedures
  4. Revlimid
    • Gen: Lenalidomide
    • Class: Immune Modulator
    • RoA: Oral
    • MOA: inhibits cell proliferation, pro-inflammatory cytokines,
    • Indication: Multiple myeloma, Myelodysplastic syndrome
  5. Neulasta
    • Gen: Pegfilgrastim
    • Class: Colony Stimulating Factor, Hematopoetic
    • RoA: SC
    • MOA: A Colony Stimulation Factor- stimulates proliferation/differentiation/ activation of hematopoietic cells
    • Indication: Febrile neutropenia, in pt with non-myeloid malignancies, Prophylaxis
  6. Remicade
    • Gen: Infliximab
    • Class: Immunological agent (TNFaI)
    • RoA: IV infusion
    • MOA: inhibits the binding of TNF alpha
    • Indication: Crohn's, Colitis, RA, psoriasis
  7. Rituxan
    • Gen: Rituximab
    • Class: Antineoplastic agent, monoclonal antibody
    • RoA: IV infusion
    • MOA: binds to CD20 antigen located on pre-B lymphocytes and may promote lysis
    • Indication: Lymphomas, Leukemias, RA
  8. Levaquin
    • Gen: Levofloxacin
    • Class: Antibiotic (fluoroquinolone)
    • RoA: Oral , IV, optical
    • MOA: inhibits topoisomerase IV, DNA gyrase (replication, transcription, repair, recombination)
    • Indication: Bronchitis, nosocomial/comm-acquired pneumonia, UTI
  9. Avastin
    • Gen: Bevacizumab
    • Class: Immunological Agent, Monoclonal antibody
    • RoA: IV infusion
    • MOA: recombinant humanized monoclonal IgG1 antibody Binds to VEGF to inhibit VEGF/Flt1 & KDR interaction of epithelial cells to prevent new blood vessels
    • Indication: Glioblastoma, Cancer (Colorectal, Renal cell Small cell lung)
  10. Zosyn
    • Gen: Piperacillin Sodium/Tazobactam Sodium
    • Class: Antibiotic
    • RoA: IV infusion
    • MOA: beta-lactam antibiotic – inhibit cell wall synthesis
    • Indication: Appendicitis, Pneumonia, Skin infection, Peritonitis, Puerperal endometritis
  11. Neupogen
    • Gen: Filgrastim
    • Class: Colony Stimulating Factor, Hematopoetic
    • RoA: SC
    • MOA: granulocyte colony stimulating factor, binds to specific cell surface receptors regulating neutrophil production, progenitor proliferation, and differentiation
    • Indication: Febrile neutropenia, harvesting peripheral stem cells
  12. Eloxatin
    • Gen: Oxaliplatin
    • Class: Antineoplastic Agent
    • RoA: IV
    • MOA: undergoes monoenzymatic conversion
    • Indication: Colon cancer – stage III, colorectal cancer
  13. Diprivan
    • Gen: Propofol
    • Class: Sedative – hypnotic
    • RoA: IV
    • MOA: unknown
    • Indication: General anesthesia, Sedation for mechanically ventilated
  14. Omnipaque
    • Gen: IOHEXOL
    • Class: nonradiocontrast agent
    • RoA: IV
    • MOA:
    • Indication: x-ray dye
  15. Integrilin
    • Gen: Eptifibatide
    • Class: Glycoprotein 2b/3a inhibitor, Platelet aggregation inhibitor
    • RoA: IV
    • MOA: inhibits platelet aggregation by binding to GP2b/3a à prevents binding of fibrinogen, vWf, and other adhesive ligand
    • Indication: Acute coronary syndrome, percutaneous coronary intervention
  16. Advair Diskus
    • Gen: Fluticasone Propionate/Salmeterol Xinafoate
    • Class: Antiasthma, Anti-inflammatory/Bronchodilator Combination
    • RoA: Inhalation
    • MOA: Fluticasone – a corticosteroid – glucocorticoid receptor agonist. Salmeterol – long acting beta agonist, stimulates AC to make cAMP à relaxes bronchial smooth muscles
    • Indication: Asthma, COPD
  17. Sodium Chloride
    • Gen: Sodium Chloride
    • Class:Antiasthma, Dermatological Agent, Dressing Agent, Eye Wash, Irrigant, Moisturizer, Nutriceutical, Osmotherapy Agent, Parenteral Electrolyte, Sodium, Respiratory Agent, Sodium Supplement, Wound Care Agent
    • RoA: Inhalation, Injection, Intravenous, Irrigation, Nasal, Ophthalmic, Oral, Sublingual, Topical
    • MOA: principle cation of extracellular fluid
    • Indication: Corneal edema, Elective abortion, Heat stroke, Hyponatremia, Hypovolemic shock, Nasal irritation
  18. Zyvox
    • Gen: Linezolid
    • Class: Antibiotic
    • RoA: IV
    • MOA: inhibits ribosomal translation by binding to 23S of 50S RNA
    • Indication: Pneumonia, Vanco-resistant Enterococcus faecium infection, infection of skin
  19. Herceptin
    • Gen: Trastuzumab
    • Class: Immunological agent, Monoclonal antibody
    • RoA: IV
    • MOA: monoclonal antibody binds to HER2 protein to inhibit the growth of tumor cells
    • Indication: Metastatic breast cancer, HER2 overexpression
  20. Protonix
    • Gen: Pantoprazole Sodium
    • Class: PPI
    • RoA: IV, nasogastric, Oral
    • MOA: inhibits the pump by binding to the pump
    • Indication: GERD, Zollinger-Ellison Syndrome, Gastric hypersecretion
  21. Taxotere
    • Gen: Docetaxel
    • Class: Antineoplastic Agent
    • RoA: IV
    • MOA: inhibits microtubule dissembly by binding to it followed by its polymerization
    • Indication: Breast cancer, Gastric cancer, Head & neck cancer, hormone refractory prostate cancer, lung cancer
  22. Angiomax
    • Gen: Bivalirudin
    • Class: Anticoagulant, Thrombin inhibitor
    • RoA: IV
    • MOA: binds to catalytic site and the anion-binding exosite of circulating and clot-bound thrombin
    • Indication: Heparin-induced thrombocytopenia, Thromboembolic disorder; Prophylaxis, coronary angioplasty, Unstable angina
  23. Thrombin-jmi
    • Gen: Bovine Thrombin
    • Class: Hemostatic
    • RoA: Topical
    • MOA: immediately clots the fibrinogen of the blood without the aid of a physiological agent
    • Indication: hemorrhage
  24. Cancidas
    • Gen: Caspofungin Acetate
    • Class: Antifungal, glucan systhesis inhibitor
    • RoA: IV
    • MOA: inhibits beta-1,3-D-glucan synthesis – an important component of cell wall
    • Indication: Aspergillosis, Candidemia, Febrile neutropenia
  25. Ultane
    • Gen: Sevoflurane
    • Class: Haloalkane
    • RoA: Inhalation
    • MOA:
    • Indication: General Anesthesia
  26. Seroquel
    • Gen: Quetiapine Fumarate
    • Class: antipsychotic
    • RoA: Oral
    • MOA: inhibits 5-HT1A, 2, D1,2, H1, and α1,2
    • Indication: Bipolar – 1, MDD, Schizophrenia
  27. Protonix IV
    • Gen: Pantoprazole Sodium
    • Class:
    • RoA:
    • MOA:
    • Indication:
  28. Gemzar
    • Gen: Gemcitabine Hydrochloride
    • Class: antimetabolite, antineoplastic agent
    • RoA: IV
    • MOA: nucleoside analogue that exhibits antitumor activity which is cell phase-specific for the S-phase and for the G1/S-phase boundary of cell division.
    • Indication: Breast, Ovarian, Pancreas, non-small cell lung cancers
  29. Erbitux
    • Gen: Cetuximab
    • Class: Antineoplastic agent, Monoclonal antibody
    • RoA: IV
    • MOA: specifically binds to EGFR blocking phosphorylation and activation of receptor-associated kinases, resulting in inhibition of growth and survival of tumor cells that over-express the EGFR
    • Indication: Head and neck cancer, Metastatic colorectal cancer
  30. Visipaque
    • Gen: IODIXANOL
    • Class: radiological non-ionic contrast
    • RoA: IV
    • MOA:
    • Indication: radiography
  31. Primaxin
    • Gen: Imipenem/Cilastatin
    • Class: Antibiotic
    • RoA: IM
    • MOA: Inhibition of cell wall synthesis
    • Indication: LRespiratory Tract, intra abdomial, skin, bynecologic infections
  32. Zocor
    • Gen: Simvastatin
    • Class: Statin
    • RoA: Oral
    • MOA: HMG-CoA reductase inhibitor
    • Indication: hypercholesterolemia (CHD, diabetes, stroke, MI)
  33. Ms Contin
    • Gen: Morphine Sulfate
    • Class: Opiate Analgesic
    • RoA: Oral
    • MOA: CNS mu opioid receptor agonist
    • Indication: Moderate to severe 24 hr pain managment
  34. vancocin
    • Gen: Vancomycin Hydrochloride
    • Class: Antibiotic
    • RoA: IV
    • MOA: Inhibition of cell wall synthesis
    • Indication: Methicillin-resistant staph, endocarditis
  35. Nexium
    • Gen: Esomeprazole
    • Class: PPI
    • RoA: Oral
    • MOA: covalently bonds to the H/K ATPase pump
    • Indication: Erosive esophagitis, GERD, NSAID-GU, H.pylori-DU, Zollinger-Ellison Sydrome
  36. Plavix
    • Gen: Clopidogrel Hydrogen Sulfate
    • Class: Anti-coagulant
    • RoA: Oral
    • MOA: Irreversibly binds to P2Y12 ADP receptors on platelets to inhibit GPIIb/IIIa complex
    • Indication: MI, Stroke, Peripheral arterial disease
  37. Zometa
    • Gen: Zoledronic Acid
    • Class: Bisphosphonate
    • RoA: IV infusion
    • MOA: inhibits osteoclasts to lower calcium release
    • Indication: Hypercalcemia of Malignacy, Multiple Myeloma, Bone Metastases
  38. Gamunex
    • Gen: Immune Globulin
    • Class: Immune Globulin
    • RoA: IV
    • MOA: supplies IgG antibodies
    • Indication: Primary Humoral Immunodeficiency (PI), Idiopathic Thrombocytopenia Purpura (ITP), Chronic Inflammatroy Demyelinating Polyneuropathy (CIDP)
  39. Camptosar
    • Gen: Irinotecan Hydrochloride
    • Class: Anti neoplastic agent
    • RoA: IV
    • MOA: binds topoisomerase-1-DNA complex
    • Indication: colon/rectum metastic carcinoma
  40. Risperdal
    • Gen: Risperidone
    • Class: Antipsychotic
    • RoA: Oral
    • MOA: D2 and 5HT2 antagonists
    • Indication: Schizophrenia, Bipolar,
  41. Zyprexa
    • Gen: Olanzapine
    • Class: Antipsyhotic (Thienobenzadiazepine)
    • RoA: Oral
    • MOA: D2, 5HT2 antagonist
    • Indication: Schizophrenia, Bipolar
  42. Lupron Depot
    • Gen: Leuprolide Acetate
    • Class: Antineoplastic Agent
    • RoA: IV, IM, ID, SC
    • MOA: Gonadaltropin-releasing Hormone (GnRH), LH-RH
    • Indication: Anemia, Endometriosis, Prostate cancer
  43. Prevacid
    • Gen: Lansoprazole
    • Class: PPI
    • RoA: Oral
    • MOA: the sulphenamide derivative binds irreversibly to the H/K ATPase pump
    • Indication: DU, GERD, NSAID-GU, Zolinger-Ellison syndrome
  44. Zithromax
    • Gen: Azithromycin
    • Class: Antibiotic (macrolide)
    • RoA: Oral
    • MOA: binds 50-S ribosomal subunit (interfers with microbial protein synthesis)
    • Indication: COPD, otitis media, conjunctivitis, pneumonia,gonorrhea (bacterial infections)
  45. Lipitor
    • Gen: Atorvastatin Calcium
    • Class: HMG-CoA reductase Inhibitor
    • RoA: Oral
    • MOA: inhibits cholesterol synthesis, increases LDL receptors
    • Indication: Hyperholesterolemia, hyper riglyceridemia, Familial type-3 hyperlipoproteinemia, CVD (prophylaxis), type 2 diabetes mellitus
  46. Cubicin
    • Gen: Daptomycin
    • Class: Antibiotic
    • RoA: IV
    • MOA: binds cell membrane depolarizing membrane potential leading to disrupt DNA, RNA and protein synthesis
    • Indication: Bacteremia, endocarditis, staph aureus
  47. Suprane
    • Gen: Desflurane
    • Class: Haloalkane
    • RoA: Inhalation
    • MOA: increase GABA transmission
    • Indication: General anesthesia
  48. Cardene I.V.
    • Gen: Nicardipine
    • Class: Anti-HT, CCBlocker
    • RoA: IV
    • MOA: blocks the transmembrane influx of Ca+ affecting cardiac/SM contractility
    • Indication: HT, postoperative HT, Stable angina
  49. Adenoscan
    • Gen: Adenosine
    • Class: Adenosine R-agonist, Antiarrhythmic
    • RoA: IV
    • MOA: depresses Lf ventricular function (influence cellular Ca dynamics)
    • Indication: Paroxysmal supraventricular tachycardia
  50. Synagis
    • Gen: Palivizumab
    • Class: Immunological Agent, Monoclonal Antibody
    • RoA: IM
    • MOA:exhibits neutralizing and fusion-inhibitory activity
    • Indication: Repiratory syncytial virus infection (RSV)
  51. Zofran
    • Gen: Ondansetron
    • Class: 5-HT3 Antagonist, Antiemetic
    • RoA: Oral
    • MOA: blocking 5-HT3 peripherally on vagal nerve terminal in CTZ (chemoreceptor trigger zone)
    • Indication: Chenotherapy/Radiation N/V
  52. Prilosec
    • Gen: Omeprazole
    • Class: PPI
    • RoA: Oral
    • MOA: irreversibly binds H/K ATPase pumps
    • Indication: DU, GU, GERD, erosive esophagitis, gastric hypersecretion
  53. Rocephin
    • Gen: Ceftriaxone Sodium
    • Class: Antibiotic (3rd Gen cephalosporin)
    • RoA: IM, IV
    • MOA: inhibition of cell-wall synthesis
    • Indication: UTI, LRTI, gonorrhea,
  54. Zemuron
    • Gen: Rocuronium Bromide
    • Class: Neuromuscular Blocker, Musculoskeletal agent
    • RoA: IV
    • MOA: competes for cholinergic receptors at the motor end-plate
    • Indication: General anesthesia
  55. Alimta
    • Gen: Pemetrexed
    • Class: Antineoplastic Agent
    • RoA: IV infusion
    • MOA: disrupts folate-dependent metabolic processes for cell replication
    • Indication: mesothelioma, small cell lung cancer
  56. Maxipime
    • Gen: Cefepime Hydrochloride
    • Class: Antibiotic (4th Gen Cephalosporin)
    • RoA: IM, IV
    • MOA: inhibits cell wall synthesis
    • Indication: Pneumonia, UTI, infections
  57. Novoseven
    • Gen: Coagulation Factor VIIA
    • Class: Hemostatic
    • RoA: IV bolus
    • MOA: promotes hemostasis by complexing tissue factor activating coagulation facotrs in intrinsic pathway
    • Indication: Hemophilia, Factor VII, VIII deficiency
  58. Lantus
    • Gen: Insulin Glargine, Recombinant
    • Class: Antidiabetic (long acting insulin)
    • RoA: SC
    • MOA: Stimulates glucose uptake by muscle
    • Indication: Diabetes mellitus type 1 & 2
  59. Optiray 320
    • Gen: Ioversol
    • Class: non radial contrast agent
    • RoA: IV
    • MOA:
    • Indication: diagnostic radiology
  60. Activase
    • Gen: Alteplase, Recombinant
    • Class: Thromolytic (tissue plasminogen activator)
    • RoA: IV
    • MOA: enhances plasminogen to plasmin by binding fibrin initiating fibrinolysis,
    • Indication: Acute MI & Ischemia, PE, venous catheter occlusion
  61. Merrem
    • Gen: Meropenem
    • Class: Antibiotic (Beta-Lactam, carbapenem)
    • RoA: IV
    • MOA: inhibiting cell wall synthesis
    • Indication: bacterial infections, meningitis, subcutaneous complication
  62. Epogen
    • Gen: Epoetin Alfa
    • Class: Erythropoietic, Hemotopoietic
    • RoA: IV, SC
    • MOA: stimulates division/differentiation of committed erythroid progenitors
    • Indication: Anemia (cancer, renal failure, Zidovudine AR, transfusion)
  63. Reopro
    • Gen: Abciximab
    • Class: Anticoagulant
    • RoA: IV
    • MOA: block platelet aggregation by binding GP IIb/IIa receptor preventing fibrinogen and other AC proteins
    • Indication: MIschemia, Refractory Angina (adjunct)
  64. Isovue-300
    • Gen: Iopamidol
    • Class: Non radial constrast agent
    • RoA: IV
    • MOA:
    • Indication: diagnostic radiology
  65. Aciphex
    • Gen: Rabeprazole Sodium
    • Class: PPI
    • RoA: Oral
    • MOA: covalently binds H/K ATPase pump
    • Indication: GU, DU, GERD, erosive esophagitis, Gastric Hypersecretion, H.pylori therapy
  66. Fentanyl
    • Gen: Fentanyl
    • Class: Analgesic (opioid)
    • RoA: SubLingual, Transdermal
    • MOA: CNS mu receptors
    • Indication: moderate-severe pain (opioid-tolerant)
  67. Combivent
    • Gen: Ipratropium Bromide/Albuterol Sulfate
    • Class: Bronchodilator
    • RoA: Inhalation, Nebulization
    • MOA: Albuterol- beta2 agonist(SM relaxation)
    • Ipratropium- anticholinergic agent (site-specific bronchodilation)
    • Indication: COPD
  68. Zoladex
    • Gen: Goserelin Acetate
    • Class: Antineoplastic agent, LHreleasing hormone agonist
    • RoA: SC
    • MOA: Inhibits/suppresses the pituitary gonadotropin secretion
    • Indication: Breast cancer, endometriosis, prostate cancer
  69. Abilify
    • Gen: Aripiprazole
    • Class: Antipsychotic
    • RoA: Oral, IM
    • MOA: Agonist at D2 and 5HT1A, antagonist 5HT2A
    • Indication: Schizophrenia, Bipolar, MDD, Autistic (agitation)
  70. Singulair
    • Gen: Montelukast Sodium
    • Class: Anti-Inflammatory (leukotriene pathway Inhibitor)
    • RoA: Oral
    • MOA: binds cysteinyl leukotrienes (CysLT) type-1 in airway to prevent edema, SM contraction and respiratory inflammation
    • Indication: Asthma, Exercise-induced A, perennial and seasonal allergic rhinitis
  71. Enbrel
    • Gen: Etanercept
    • Class: Immune Suppressant (TNFalpha inhibitor)
    • RoA: SC
    • MOA: Binds to TNFa,b receptor inactivation inflammatory/ immune response, and other cytokines
    • Indication: RA, Juvenile Idiopathic arthritis, Psoriasis
  72. Magnevist
    • Gen: Gadopentetate Dimeglumine
    • Class: Non-ionic contrast media
    • RoA: IV
    • MOA:
    • Indication: Diagnostic Radiology
  73. Argatroban
    • Gen: Argatroban
    • Class: Anticoagulant
    • RoA: IV
    • MOA: binds active thrombin site to inhibit
    • Indication: Coronary Artery Thrombosis, Heparin-induced Thrombocytopenia
  74. Thymoglobulin
    • Gen: Lymphocyte Immune Globulin
    • Class: Immune Supressant
    • RoA: IV
    • MOA: Clears and suppresses T-cell activation
    • Indication: Renal transplant rejection (adjunct)
  75. Novolog
    • Gen: Insulin Aspart, Recombinant
    • Class: Antidiabetic (rapid acting insulin)
    • RoA: SC
    • MOA: binds insulin receptors on muscle and fat cells to increase glucose uptake
    • Indication: Diabetes mellitus types 1 & 2
  76. Ambisome
    • Gen: Amphotericin B Liposome
    • Class: Antifungal (polyene)
    • RoA: IV
    • MOA: binds to ergosterol in cell membranes causing permeability, leaking and cell death
    • Indication: fungal infections (aspergillosis, candidiasis, meningitis-HIV, pumonary aspergillosis)
  77. Cipro IV
    • Gen: Ciprofloxacin
    • Class: Antibiotic (Fluoroquinolone)
    • RoA: IV, Oral
    • MOA: Interference of DNA gyrase(DNA synthesis)
    • Indication: bacterial infections (Anthrax, gonorrhea, bronchitis, nosocomial pneumonia, LRTI, UTI)
  78. Sandostatin Lar
    • Gen: Octreotide Acetate
    • Class: Somatostatin (Endocrine-metabolic agent)
    • RoA: SC, IV, IM
    • MOA: reduces growth hormone, LH, GnRH
    • Indication: Acromegaly, Carcinoid Syndrome, Vasoactive Intestinal Peptide-Secreting Tumor
  79. Keppra
    • Gen: Levetiracetam
    • Class: Anticonvulsant
    • RoA: IV, Oral
    • MOA: prevents hypersynchronization of epileptiform burst firing and propagation
    • Indication: Partial, Myoclonic, Tonic-clonic Seizures
  80. Albuminar-25
    • Gen: Albumin Human
    • Class: Volume Expander
    • RoA: IV
    • MOA: increases volume and plasma
    • Indication: ARespiratory Distress, Ascites, Burns, liver failure, Nephropathy, Pancreatits
  81. Botox
    • Gen: Onabotulinumtoxin-A
    • Class: Musculoskeletal agent, Botulinum Toxin Type A
    • RoA: IV, IM
    • MOA: blocks neuromuscular conduction on motor nerve terminals, inhibiting acetylcholine release
    • Indication: Blepharospasm, headache, hyperhidrosis of axilla, incontinence (detrusor instability), strabismus, upper limb spasticity, wrinkled face
  82. Venofer
    • Gen: Iron Sucrose
    • Class: Parenteral Mineral-Trace Mineal
    • RoA: IV
    • MOA: dissociates to iron and sucrose components, increases iron, ferritin levels, decreases total iron binding capacity
    • Indication: Iron deficiency anemia
  83. Paclitaxel
    • Gen: Paclitaxel
    • Class: Antineoplastic agent, Mitotic Inhibitor
    • RoA: IV
    • MOA: enhances the cytotoxic effects of ionizing radiaion
    • Indication: Breast, Ovarian, small cell lung cancer, AIDS-related Kaposi's sarcoma
  84. Effexor Xr
    • Gen: Venlafaxine Hydrochloride
    • Class: Antidepressant (phenethylamine- SNRI)
    • RoA: Oral
    • MOA: inhibits 5HT, NE, Da reuptake
    • Indication: GAD, MDD, Panic disorder, Social Phobia
  85. Neurontin
    • Gen: Gabapentin
    • Class: Anticonvulsant (GABA enhancement)
    • RoA: Oral
    • MOA: increases GABA
    • Indication: Partial Seizure, Postherpetic Neuralgia
  86. Aloxi
    • Gen: Palonosetron Hydrochloride
    • Class: Antiemetic (5HT3 antagonist)
    • RoA: IV
    • MOA: inhibits the vomiting reflex
    • Indication: Chemotherapy-induced N/V
  87. Gardasil
    • Gen: Human Papillomavirus Vaccine
    • Class: Vaccine
    • RoA: IM
    • MOA: develops humoral immune response against paps 6, 11, 16, and 18.
    • Indication: viruses associated with cancer treatment
  88. Trasylol
    • Gen: Aprotinin
    • Class: Hemostatic
    • RoA: IV
    • MOA: unknown but maintains platelet function, prevents fibrinolysis
    • Indication: Hemorrhage (surgery)
  89. Xigris
    • Gen: Drotrecogin Alfa
    • Class: Anticoagulant, Profibrinolytic
    • RoA: IV
    • MOA:
    • Indication: Sepsis syndrome from organ dysfuction (pulled from market)
  90. Glucophage
    • Gen: Metformin Hydrochloride
    • Class: Biguanide, Hypoglycemic
    • RoA: Oral
    • MOA: 1. decreases hepatic glucos production
    • 2. decreases intestinal absorption,
    • 3. increases peripheral glucose uptake
    • 4. improves insulin sensitvity
    • Indication: Diabetes Mellitus type 2
  91. Xopenex
    • Gen: Levalbuterol
    • Class: Bronchodilator (Beta-2 agonist)
    • RoA: Inhalation
    • MOA: relaxation of airway SM
    • Indication: Asthma
  92. Prograf
    • Gen: Tacrolimus
    • Class: Antipsoriatic, Immune Suppressant, Calcineurin Inhibitor
    • RoA: IV, Oral, topical
    • MOA: Inhibits T-lymphocyte activation, and other cytokines
    • Indication: transplant rejection, atopic dermatitis

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