Pharm Anti-neoplastic

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Author:
nicstrain
ID:
12737
Filename:
Pharm Anti-neoplastic
Updated:
2010-04-05 22:40:36
Tags:
USMLE
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Description:
Anit-neoplastic drugs
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  1. Cyclosporine
    • Protects against rejections from organ transplants
    • does not induce bone marrow depression
  2. Cyclophosphamide
    • Ankylating agent of both purine and pyrimide bases of DNA
    • Tx - CLL
  3. Cisplatin's Toxicities
    Nephro & Ototoxicity
  4. Methotrexate
    • Antimetabolite of folic acid (folic acid analog): (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase
    • Tx for ALL and Psoriasis
  5. Leucovorin Rescue
    Can block/reduce Methotrexate = increase folic acid via reduced folate
  6. Bleomycin Toxicity's
    pneumonities & pulmonary fibrosis
  7. Azathiorine
    • Used in organ transplantation = kidney allografts
    • Allopurinol can increase its activity by (-) its biotransformation to xanthine oxidase
  8. MOPP
    • Chemotherapy used in the tx of Hodgkin's Disease
    • M = Mechlorethamine - nitrogen mustard
    • O = Oncovin (Vincristine) - prevents microtubule assembly
    • P = Procarbazine
    • P = Prednisone - glucocorticoid, including apoptosis
  9. Tamoxifen
    • (-) estrogen receptor
    • Tx of breast tumors can see associated endometrial Ca
  10. Flutamide
    • Antiandrogenic
    • Used w/ Leuprolide (LH-RH analog)
    • Tx prostatic Ca
  11. Megestrol
    • (-) progesterone receptor
    • Tx endometrial ca
  12. Fluoxymesterone
    • Androgenic steroid
    • tx mammary ca in postmenopausal woman
  13. Brain Tumor tx
    • Lomustine
    • Carmustine - causes pulmonary fibrosis
  14. Streptozocin
    • Attaches to Beta cells
    • tx of pancreatic insulinomas
  15. Cytarabine (AraC)
    • Pyrimidine analog
    • DOC for AML
  16. Dactinomycin
    Used for Wilms tumor and rhabdomyosarcoma
  17. Etoposide
    Used for Oat cell Ca
  18. Paclitaxel
    Used for ovarian Ca
  19. Amifostine
    Can decrease nephrotoxicity due to chronic use of Cisplatin

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