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Most Na reabsorbtion occurs in the
Proximal convulated tubule
Aldosterone secreted by
Carbonic Anhydrase Inhibitors (where, what drugs)
- Proximal convoluted tubule
- Bicarb not reabsorbed into blood, accumulates along with Na. Water follows Na.
- Also causes systemic acidosis
Osmotic diuretics locations (3), MOA, drug
- Proximal convoluted tubule, descending loop, collecting duct.
- Increases osmotic pressure within the tubule, reabsorbtion of water reduced, more pee
Loop diuretics location, MOA, drugs (2)
- Ascending thick limb of loop of Henle
- Inhibit Na/K/Cl symporter. -> retention fo Na, K and Cl in the tubule. Increased pee pee
- Ethacrynic acid
Thiasize diuretics location, MOA, drugs (2)
- Distal convoluted tubule
- Block Na/Cl transport from luminal side of epithelial cells, increase urine out put **longterm vasodilation**
- HCTZ, Chlorthalidone
Aldosterone Antagonists location, MOA, drugs
- Collecting duct
- Inhibit aldosterone, reduce Na reabsorption and reduce K secretion
- Spironolactone, eplerenone