Diuretics

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Author:
jaguavai
ID:
127480
Filename:
Diuretics
Updated:
2012-01-12 17:11:12
Tags:
Pharm 421
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Description:
Diuretics
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  1. Most Na reabsorbtion occurs in the
    Proximal convulated tubule
  2. Aldosterone secreted by
    Adrenal Cortex
  3. Carbonic Anhydrase Inhibitors (where, what drugs)
    • Proximal convoluted tubule
    • Acetazolamide
  4. CAI MOA
    • Bicarb not reabsorbed into blood, accumulates along with Na. Water follows Na.
    • Also causes systemic acidosis
  5. Osmotic diuretics locations (3), MOA, drug
    • Proximal convoluted tubule, descending loop, collecting duct.
    • Increases osmotic pressure within the tubule, reabsorbtion of water reduced, more pee
    • Mannitol
  6. Loop diuretics location, MOA, drugs (2)
    • Ascending thick limb of loop of Henle
    • Inhibit Na/K/Cl symporter. -> retention fo Na, K and Cl in the tubule. Increased pee pee
    • Furosemide
    • Ethacrynic acid
  7. Thiasize diuretics location, MOA, drugs (2)
    • Distal convoluted tubule
    • Block Na/Cl transport from luminal side of epithelial cells, increase urine out put **longterm vasodilation**
    • HCTZ, Chlorthalidone
  8. Aldosterone Antagonists location, MOA, drugs
    • Collecting duct
    • Inhibit aldosterone, reduce Na reabsorption and reduce K secretion
    • Spironolactone, eplerenone

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