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- Partial pressure of CO₂
- Directly related to pH
- Partial pressure of O₂
- High pO₂ = oxygen binds readily to haemoglobin that is present.
- Low pO₂ = oxygen is released
O₂ affinity and pH / pCO₂
- ↑ pCO₂ → ↑ CO₂ → ↓ pH → ↑ acidic → ↓ Hemoglobin O₂ affinity → release of O₂
- Vice versa → binding of O₂
- This is known as the Bohr effect
- Where a decrease in pCO₂ / pH (acidity) causes an increase in the quantity of Oxygen that binds to hemoglobin (and vice versa).
- So as more CO₂ is created and diffuses into the blood, then pH becomes more acidic, so more O₂ is released out to the cells.
- The opposite is also the case, where alkalosis caused hemoglobin to hang on more tightly to the O₂
- Upshot of this is that O₂ binds to Hemoglobin in the lungs and is released to the tissues of the body.
- 2nd most abundant chemical in RBCs aside from hemoglobin
- Affects hemoglobins affinity for O₂
- Hypoxia → ↑ DPG → curve moves right and → ↑ O₂ released
Temperature and pO₂
Fevers enhance oxygenation of peripheral tissues and organs
Exercise and pO₂
↑ Temp + ↑ CO₂ (thus ↓ pH) → enhanced oxygenation of tissues