Card Set Information
Partial pressure of CO₂
Directly related to pH
Partial pressure of O₂
High pO₂ = oxygen binds readily to haemoglobin that is present.
Low pO₂ = oxygen is released
O₂ affinity and pH / pCO₂
↑ pCO₂ → ↑ CO₂ → ↓ pH → ↑ acidic → ↓ Hemoglobin O₂ affinity → release of O₂
Vice versa → binding of O₂
This is known as the Bohr effect
Where a decrease in pCO₂ / pH (acidity) causes an increase in the quantity of Oxygen that binds to hemoglobin (and vice versa).
So as more CO₂ is created and diffuses into the blood, then pH becomes more acidic, so more O₂ is released out to the cells.
The opposite is also the case, where alkalosis caused hemoglobin to hang on more tightly to the O₂
Upshot of this is that O₂ binds to Hemoglobin in the lungs and is released to the tissues of the body.
2nd most abundant chemical in RBCs aside from hemoglobin
Affects hemoglobins affinity for O₂
Hypoxia → ↑ DPG → curve moves right and → ↑ O₂ released
Temperature and pO₂
Fevers enhance oxygenation of peripheral tissues and organs
Exercise and pO₂
↑ Temp + ↑ CO₂ (thus ↓ pH) → enhanced oxygenation of tissues