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Mechanism of Action;
prolongs duration of action potential and effective refractory period; non-competitive a and b-adrenergic inhibitions; increases PR and QT intervals; decreases sinus rate, decreases peripheral vascular resistance
Ventricular tachycardia, ventricular fibrillation, cardiac arrest, supraventricular tachycardia, atrial fibrillation, atrial flutter, PSVT, WPW
Contraindications & Precations;
Contraindications; 2nd and 3rd degree blocks, bradycardia, neonates, infants Precautions; CHF, severe hepatic, respiratory diseases, children; half-life 40 days
Route and Dosage;
- Cardiac arrest; 300 mg IVP. May repeat 150 mg q 3-5 min. Max; 2,200 mg/24 h. Maintenance Infusion; mix 1000 mg in 500 ml; run at 15 ml/hr or 15 microgtt/min
- Ventricular dysrhythmias; 150 mg over 10 minutes. May repeat 150 mg every 10 min
Adverse reactions and side effects;
sinus arrest, CHF, dysrhythmias, SA node dysfunction; hepatotoxicity; ARDS
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