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Mechanism of Action;
Slows conduction through AV node; inhibits reentry pathways through AV node
to convert SVT to sinus rhythm, as a diagnostic aid
Contraindications & Precautions;
- Contraindications; 2nd or 3rd degree heart block; AV block, Atrial flutter, Atrial fibrillation, VT.
- Precautions; Pt may transiently develop asystole, PVCs, PACs, sinus bradycardia, and sinus tachycardia after administration; asthma
Route & Dosage;
IV; 6 mg rapid IV bolus, followed in 1-2 min. with 12 mg if no response. May admin. An additional 12 mg. (Peds 0.05 mg/kg,) may be increased by 0.05 mg/kg every 2 minutes to a max of .25 mg/kg. Note: rapid bolus is crucial – half-live is ~ 10 seconds; · Follow rapid IV bolus (in proximal IV site) with rapid IV flush of NS.
Adverse reactions and side effects;
dyspnea, prolonged asystole in patients taking Dipyridamole (Persantine, an antiplatelet agent) or Tegretol (an anti-seizure drug)
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