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Mechanism of Action;
Inhibits calcium ion influx across cell membrane during cardiac depolarization; decreases conduction velocity and ventricular rate; produces relaxation of coronary vascular smooth muscle, slows AV node conduction
Atrial fibrillation, atrial flutter, PSVT ·
Contraindications & Precautions;
Contraindications; 2nd or 3rd degree block, hypotension (SBP <90), AMI.
Precautions; CHF, hypotension.
Route and Dosage;
0.25 mg/kg bolus over 2 min.; may repeat at 0.35 mg/kg after 15 min. (avg initial dose 25 mg) ·
Adverse reactions and side effects;
heart block, hypotension, bradycardia, CHF.
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