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Mechanism of Action;
essential for muscle contraction; causes CNS depression and controls seizures by blocking release of acetylcholine at the myoneural junction; decreases sensitivity of motor end plate to acetylcholine and decreases excitability of motor membrane.
correct hypomagnesemia in Torsade de pointes, ventricular fibrillation, ventricular tachycardia, cardiac arrest; management of eclampsia of pregnancy, , status asthmaticus
Contraindications & Precautions;·
- Contraindications; hypocalcemia, heart block; do not administer in toxemia during the 2-hour period before delivery.
- Precautions; rapid IV administration. May cause respiratory or cardiac arrest
Route and Dosage;
Cardiac arrest: 1-2 gm in 10 ml IVP; Torsade de pointes; 1-2 gm in 50-100 ml of NS IV over 5-20 min.; Eclampsia: 4 – 5 g IV infusion over 5-10 min
Adverse reactions and side effects;
- resp. depression and arrest, arrhythmias, hypotension;
- to reverse these effects, hyperventilate pt. and admin. IV bolus of 10% calcium gluconate 10-20 ml.
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