sem 2 biochem

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sweetlu
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128183
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sem 2 biochem
Updated:
2012-04-11 14:03:31
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sem biochem
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sem 2 biochem
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  1. MAOI's
    • MAO-A for 5-HT(seratonin)
    • MAO-B for dopamine
  2. tricyclic antidepressants
    inhibit the high affinity uptake of NE and 5-HT(seratonin)
  3. SSRI
    inhibit the high affinity uptake of 5-HT(seratonin) ONLY
  4. cocaine and ritalin
    • inhibit the uptake of dopamine, NE and 5-HT
    • - cocaine- short half-life
    • - ritalin- long half-life
  5. amphetamine
    releases dopamine, 5-HT and NE from nerve terminals
  6. barbituates
    • - stimulate GABA-A receptor (Cl- channel that opens in response to GABA
    • - suicide risk
  7. benzodiazepines
    • - sensitize the GABA-A receptor
    • - NO suicide risk
    • - eg, Valium
  8. eicosanoid syndrome
    - tumor that over produces 5-HT
  9. Pentose Phosphate p/w
    • - G-6-PDH is main enzyme
    • - main products NADPH and Ribulose-5-Phosphate
    • -G6PDH inhibited by NADPH
  10. Transketolase
    • - activity is a sign of thiamine status
    • - part of the nonoxidative branch of the PPP along with transaldolase
  11. Polyol p/w
    -make fructose from glucose for use in seminal vesicles
  12. incretins
    - augment insulin secretion by 3-4 times
  13. GLP-1
    • - glucagon like polypeptide
    • - increases satiety
    • - increases insulin secretion
    • - decreases gastric emptying
  14. GLUT 1
    • - brain glucose transporter
    • - NON insulin dependent
  15. GLUT 2
    • - hepatocytes (liver)
    • - NON insulin dependent
  16. GLUT 4
    • - CM, SkM and adipose tissue
    • - insulin dependent
  17. HbA1C
    • - goal < 7.0%
    • - glycosylated Hb- an indicator of BG over last 120 days
  18. leptin
    • - Th1 stimulation, Th2 inhibition
    • - decreases food intake, bone formation
    • - increases energy expienditure (beta-ox), SNS activity
    • - uses JAK-STAT p/w
    • - increases inflammation (TNF and IL-6)
  19. adiponectin
    • - increases glucose uptake
    • - decreases gluconeogenisis
    • - increases beta-oxidation
    • - prevents plaque formation
    • - reduces inflammation (IL-10 IL-1RA)
  20. TNF gamma
    • - induces insulin resistance
    • - promotes lipolysis
    • - down regulates adiponectin
    • - up regulates IL-6 and IL1 (proinflammatory)
  21. IL-6
    • - increases adipolysis
    • - increases FA oxidation
    • - increases serum glucose
    • - down regulates IRS-1
    • - down regulates adiponectin
  22. curare
    - blocks Nm receptors in the muscles
  23. Atropine and scopalamine
    - block M receptors
  24. rate limiter in catecholamine synthesis
    - tyrosine hydroxylase

    -(DA->NE->Epi)
  25. rate limiter in catecholamine and indoleamine inactivation
    - uptake on CT's by high affinity Na cotransporter
  26. aa NT's
    - excitatory- glu and asp

    - inhibitory- gly
  27. glutamate decoarboxylase
    • - glutamate--> GABA
    • - deficiency==> seizures
    • - coez= B6

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