Type 2 diabetes
potentiates the effect of endogenous insulin. May work by decreasing hepatic glucose production and improving insulin sensitivity
N/V/D, flatulence, rash, weakness, HA, hypoglycemia, lactic acidosis, myalgia, blood dyscrasias, chest discomfort, etc.
Caution is used when the drug is administered with other meds that lower blood glucose due to increased risk of hypoglycemia.
- Comments: renal function should be monitored. The drug may be discontinued in renal dysfunction.
- - Medication is held before surgeries and use of contrast media.
- - Best effect is 1-2% reduction in A1c
- - D:D interactions with some SOP meds (ie Trimethoprim and oral fluoroquinolones)