We accidentally gave a patient an overdose of an alkaline drug that is normally excreted in the urine. In order to use ion trapping to help excrete the drug faster, should we alkalinize or acidify the urine, and why?
we should acidify the urine. This puts the alkaline drug in an acidic environment, it will be “unhappy”, it will ionize, and be mostly hydrophilic and water soluble. The drug will now stay in the watery urine and be less likely to cross the lipid cell membranes of the kidney tubule cells and get back into the patient’s blood.