Hematology II Unit 1

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maravi80
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128861
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Hematology II Unit 1
Updated:
2012-05-03 15:40:40
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Anemias
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Anemias
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  1. Define anemia.
  2. Using morphologic classification of the anemia, what are the categories and their indices.
  3. List the normal CBC ranges for male and females.
  4. What is a reticulocyte and when are values increased and decreased?
  5. How does anemia effect the reticulocyte count and what is the formula to correct the count?
  6. What is Reticulocyte Production Index and what does a value greater than 2 and less than 2 indicate?
  7. What is the normal myeloid/erythroid ratio?
    3:1
  8. What iron stains are done on bone marrow and why are they ordered?
    Prussian blue to demonstrate the presence of hemosiderin. They are ordered to see if body iron stores are normal or increased.
  9. What are the normal values for serum iron, TIBC and percent saturation?
  10. What does an increased bilirubin and urobilinogen indicate?
  11. Describe erythrocyte survival studies (chromium 51 studies) and why they are used.
  12. While investigating an anemia, when is hemoglobin electrophoresis helpful?
  13. Why is the Antiglobin Test helpful in investigating and anemia?
  14. What is serum ferritin and why is it measures?
  15. What is the normal value for Free Erythrocyte Protoporphyrin and what does an increased value indicate?
  16. List the main causes of microcytic hypochromic anemia.
  17. List the main reasons for iron deficiency anemia.
  18. Describe the symptoms of iron deficiency anemia.
  19. What test are helpful in the diagnosis of iron deficiency anemia and what values are expected?
  20. Describe the peripheral blood and bone marrow picture in iron deficiency anemia.
  21. How is response to treatment of iron deficiency monitored.
  22. What laboratory tests are used to distinguish between iron deficiency anemia and siderblastic anemia? What values would you expect for each?
  23. What are the two main classifications of siderblastic anemia?
  24. Which anemia responds to pyridoxine supplements?
  25. What is a ringed sideroblast?
  26. What are the clinical symptoms of siderblastic anemia?
  27. Describe the peripheral blood and bone marrow in siderblastic anemia.
  28. Describe the mechanism for anemia of chronic disease.
  29. Define porphyria.
  30. How are porphyrins effected by UV light?
  31. Differentiate between Erythropoietic porphyria and erythropoietic protoporphyria.
  32. Where is the basic defect in megablastic anemias?
  33. What percent of megaloblastic anemias are caused by B12 or folic acid deficiency?
  34. Describe the peripheral blood picture in a classic megaloblastic anemia.
  35. Why is intrinsic factor important?
  36. What can cause defective absorption of vitamin B12?
  37. What is pernicious anemia?
  38. List the clinical symptoms of pernicious anemia.
  39. Describe the peripheral blood and bone marrow in pernicious anemia.
  40. What result would you expect for gastric analysis in pernicious anemia?
  41. Describe the Schilling test and explain how to differentiate between pernicious anemia and malabsorption.
  42. List the usual causes of a folic acid deficiency.
  43. What differance is there between the symptoms of folic acid deficiency and pernicious anemia.
  44. List causes macrocytic anemia without megaloblastosis.
  45. What tests would you look at first to differentiate between megaloblastic and non megaloblastic macrocytic anemias.
  46. List general causes of normocytic/normochromic anemia.
  47. What is aplastic anemia and how is diagnosis made? Include pertinent laboratory data.
  48. Briefly discuss causes of aplastic anemia.
  49. Define myelophthisic anemia and briefly describe the peripheral blood and bone marrow.
  50. Define myelodysplastic syndrome and

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