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what are thrombocytes?
platelets, cytoplasmic fragments
what do thrombocytes look like?
- smaller than RBC
where are thrombocytes made?
in the bone marrow
what is the function of thrombocytes?
hemostasis (starts clotting process)
how are thrombocytes produced in the bone marrow?
megakaryoblast divides and turns into promegakaryoctyes. promegakaryocytes divide and turns into megakaryocyte, the platelets then break off
how long are platelets lifespan in circulation?
about 10 days
greater than normal thrombocytes
less than normal thrombocytes
not able to function correctly in clotting mechanism
what is the normal range for thrombocytes?
- 200,00 - 500,000/ul
- clinical signs once below 50,000/ul
what are the clinical signs of an animal with too little thrombocytes
- unable to clot blood
- spontaneous mucosal bleeding (epistaxis & hematuria, melena & ocular hemorrhage, gingival bleeding, bruising/echymoses, petechial hemorrhages
how to estimate the total number of platelets
- count the total number of platelets in 10 fields
- multiply by 1500
what are the mechanisms of thrombocytopenia?
- decreased production
- increased destruction
- sequestration (can't get out of the spleen)
what are shift platelets?
bigger than normal platelets
what causes shift platelets?
breaking off early due to an increased demand