Depression Drugs MOA

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Author:
bigfootedbertha
ID:
129807
Filename:
Depression Drugs MOA
Updated:
2012-01-22 19:24:37
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Depression Drugs MOA
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Depression Drugs MOA
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  1. MOAIs
    inhibit enzyme responsible for intraneuronal breakdown of 5-HT, NE, and DA
  2. TCAs
    • 5-HT/SRI/NRI
    • "dirty receptors":
    • a1-adrenergic
    • histamine-1
    • muscarinic anticholinergic
  3. Bupropion
    norepinephrine/dopamine reuptake inhibitor
  4. Venlafaxine/desvenlafaxine/duloxetine
    • 5-HT and NE reuptake inhibitors
    • weak inhibitors of DA reuptake
    • Duloxetine has balanced SRI and NRI activities and higher affinity for the reuptake sites
  5. Nefazodone
    • 5-HT antagonists/reuptake inhibitors
    • 5-HT activity not as great as SSRIs, but portently block 5-HT2a receptors, which allows more 5-HT to interact at postsynaptic 5-HT1a sites
  6. Trazodone
    • 5-HT antagonists/reuptake inhibitors
    • 5-HT activity not as great as SSRIs, but portently block 5-HT2a receptors, which allows more 5-HT to interact at postsynaptic 5-HT1a sites
    • Also blocks histaminergic and a-adrenergic receptors (nefazodone is weak)
  7. Mirtazapine
    • noradrenergic and specific serotonergic
    • blocks presynaptic a2 receptors, both autoreceptors on noradrenergic neurons and heteroreceptors on serotonergic neurons => increase NE and 5-HT synaptic concenrations
    • Blocks various postsynaptic serotonergic receptors and histamine-1 receptors

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