Epilepsy Metabolism

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  1. CBZ
    • CYP3A4
    • **induces CYP3A4 and 2C9**
  2. ETS
    oxidized metabolites, specific enzymes unknown
  3. GBP
    eliminated unchanged renally
  4. LCM
    • 50% excreted renally unchanged
    • 50% metabolized by CYP3A4
  5. FBM
    metabolized mostly by non-CYP enzymes, some 3A4
  6. LEV
    mostly eliminated unchanged, some hydrolysis
  7. LTG
    Metabolized by glucuronidation
  8. OXC
    Metabolized by alcohol dehydrogenase and follwed by glucuronidation
  9. PGN
    Nearly 100% renally eliminated unchanged
  10. PHB
    • Extensively oxidized to hydroxyl metabolite (specific CYP unknown) followed by glucuronidation
    • **Induces many CYP450 isoforms and UGT (phase II)**
  11. PHT
    • Extensively metabolized by CYP2C9 and 2C19
    • **induces many CYP450 isoforms and UGT (phase II)**
  12. TGB
    Extensively metabolized by CYP3A4
  13. TPM
    Mostly excreted renally unchanged; some CYP450 metabolism occurs
  14. VPA
    • Extensively metabolized by non-CYP oxidation and glucuronidation
    • **Inhibits CYP2C9 and glucuronidation
  15. ZNS
    • Metabolized by CYP3A4
    • Extended renally as phase II metabolites and unchanged drug
Card Set
Epilepsy Metabolism
IP 7
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