Epilepsy Metabolism

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CBZ
- CYP3A4
- **induces CYP3A4 and 2C9**
ETS

oxidized metabolites, specific enzymes unknown
GBP

eliminated unchanged renally
LCM
- 50% excreted renally unchanged
- 50% metabolized by CYP3A4
FBM

metabolized mostly by non-CYP enzymes, some 3A4
LEV

mostly eliminated unchanged, some hydrolysis
LTG

Metabolized by glucuronidation
OXC

Metabolized by alcohol dehydrogenase and follwed by glucuronidation
PGN

Nearly 100% renally eliminated unchanged
PHB
- Extensively oxidized to hydroxyl metabolite (specific CYP unknown) followed by glucuronidation
- **Induces many CYP450 isoforms and UGT (phase II)**
PHT
- Extensively metabolized by CYP2C9 and 2C19
- **induces many CYP450 isoforms and UGT (phase II)**
TGB

Extensively metabolized by CYP3A4
TPM

Mostly excreted renally unchanged; some CYP450 metabolism occurs
VPA
- Extensively metabolized by non-CYP oxidation and glucuronidation
- **Inhibits CYP2C9 and glucuronidation
ZNS
- Metabolized by CYP3A4
- Extended renally as phase II metabolites and unchanged drug

Author

129870

Card Set

Epilepsy Metabolism

Description

IP 7

Updated

2012-01-23T04:19:06Z

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