Endo 3 - hypothal and ant pit

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  1. mechanism of neurosecretory cells
    • peptide hormones are packages into the secretory granules within golgi apparatus
    • once packaged, it's carried along the axoplasmic transport
    • along the transport, the larger proteins or hormones are broken into smaller hormones (final product) and stored in the hering bodies
    • the hormones are released by action potentials
  2. GnRH
    • decapeptide
    • exogenous (outside) GnRH, when given to patients it causes spematogenesis in males and ovulation in females
    • infetility is treated by exogenous GnRH
    • also regulated GnRH receptors in brain by ultra-short loop (was used for male contraception)
  3. Circulation of Hypothalamus
    • blood supply is by hypothalamo hypophysial portal system
    • hypothalamus is highly vascularized - trauma causes bleeding and death
    • hypothalamus is supplied by circle of willis (internal carotic artery and posterior artery and medial hypophysial artery)
    • veins of galen are responsible for blood draining
  4. circulation of anterior pituitary
    • blood from superior hypophysial arteries (comes from interal carotid arteries) which flows through primary capillary plexus into the medium eminence and pituitary stalk
    • from primary plexus --> arises hypophysial portal system which ends in anterior pituitary to form secondary plexus, which supplies blood to the secretory cells
    • blood drains by efferent veins

    posterior pituitary is supplied by inferior hypophysial artery
  5. hypothalamus
    • below the thalamus
    • full of nervous tissue
    • controls most of body activities, bot only hormones releasing
  6. portal hormones
    different factors released in the hypothalamic portal system, which controls anterior pituitary hormones
  7. systematic hormones
    posterior pituitary hormones are released into circulation
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Endo 3 - hypothal and ant pit
endo exam 1
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