Common drugs for arthritis and connective tissue disease

The flashcards below were created by user dsherman on FreezingBlue Flashcards.

  1. NSAID's
    Dosage: vares depending on which drug is being used

    Purpose: relieves chronic pain by inhibiting prostaglandin synthesis

    Nursing Implications: observe for fluid retention, increased blood pressure, and changes in renal function

    tionales: Most NSAID's cause sodium retention, which can lead to edema, hypertension, renal damage, and heart failure. Drugs should be used with caution in older adults

    Monitor electrolyte and CBC values; most NSAID's cause increased sodium levels and can cause bone marrow suppression

    Observe for CNS changes (dizziness, confussion); most NSAID's can cause CNS effects, especially in older adults
  2. Hydroxychloroquine sulfate (Plaquenil)
    • Dosage: 200mg orally daily
    • Purpose: an antimalarial agent that helps decrease inflammation and slow disease process

    Nursing implications: instruct patient to have frequent (every 6-12 months) ophthalmologic examination

    Rationale: drug can cause retinal damage
  3. Immunosuppressive agents (e.g., methotrexate [Rheumatrex]most commonly used, azathioprine [Imuran], cyclophosphamide [cytoxan])
    Purpose: supresses bone marrow to reduce immune response

    Nursing implications:Monitor for side effects and toxic effects, including buat not limited to nausea/vomiting, bone marrow suppression, and increased liver enzymes

    instruct patient to avoid crowds and people with infections such as influenza, if ill seek medical attention

    Rationale: the side effects ans toxic effects of these drugs can be devastating

    immune suppression increases the risk of infection
  4. Prednisone (Deltasone, Ao-prednisone)
    Purpose: decreases inflammatory and immune response by decreasing WBC count

    • Nursing implications: observe for cushingoid changes, buffalo hump, moon face, striae, acne, thin skin, bruising, fluid retention, and increased blood pressure.
    • Monitor electrolyte and glucose levels. Monitor weight.

    Rationale: these changes are expected and tend to be dose related changes diminish as dose decreases

    chronic steroid therapy can cause sodium or fluid retention, potassium depletion, and elevated glucose level

    • Nursing implications cont: observe for long-term effects of chronic steroid therapy, such as osteoporosis, attaracts, hypertension diabetes, and impaited healing
    • Rationale: these complications may need to be treated with other drugs or modalities

    Teach patient to increase dietaty calcium and vitamin D and take supplement

    instruct patient to avoid crowds and persons with infections such as influenza

    Rationale: drug suppress immune system (lymphocytes) and increases risk of infection or decreased healing
  5. Sulfasalazine (Azulfidine)
    Purpose: decreases inflammation and slows disease process

    Nursing implications: check for sulfa allergy or kidney or liver disease

    teach patient to drink adequate fluids

    teach men that the drug can lower sperm count

    Rationales: drug is a sulfa medication that has potential renal/liver toxicities

    failure to drink fluids may cause formation of urine crystals

    low sperm count may interfere with ability to conceive
  6. Leflunomide (Arava)
    Purpose: decreases inflammation by inhibiting an enzyme

    Nursing implcations: teach patient to have prescribed laboratory test, usually every 6-8 weeks

    avoid alcohol while taking drug

    Rationales: increased liver enzymes and decreased bloood count have been reported

    alcohol can increase liver enzymes
  7. Biological response modifiers(BRMs)
    Purpose: Neutralize biological activity of either TNF or IL to decrease immune response

    Nursing implications: do not give BRMs if patient has a serious infection, TB, or MS

    Rationale: drugs may exacerbate infections, MS, or lupus
  8. BRMs
    Etanercept (Enbrel)
    Infliximab (Remicade)
    Adalimumab (Humira)
    Anakinra (Kineret)
    Abatacept (Orencia)
    Rituximab (Rituxan)
    Nursing implication:
    • teach patient to report site reaction
    • refrigerate to prevent decomposition
    • report chest pain
    • difficulty breathing during infusion
    • monitor blood pressure
    • monitor WBC count
    • report cough, dizziness, and sore throat
    • monitor for dyspnea, wheezing, flushing, itching
    • observe for infusion reaction
  9. Infliximag (Remicade)
    Do not refrigerate it is the only BRM that you do not refrigerate
Author
ID
130493
Card Set
Common drugs for arthritis and connective tissue disease
Description
Common drugs for arthritis and connective tissue disease
Updated
Show Answers