Nursing 4 Lecture 3 Autoimmunity LABS

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ncappadonia
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Nursing 4 Lecture 3 Autoimmunity LABS
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2012-01-25 13:17:50
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Nursing 4 Lecture 3 Autoimmunity LABS
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  1. ACA (Anticardiolipin Antibody)
    • NORMAL FINDINGS:
    • - <23 GPL (IgG phospholipid units)
    • - <11 MPL (IgL phospholipid units)

    This test is positive in some patients with systemic lupus erythematosus (SLE)

    • Interfering Factors:
    • False positives in patients who take medications such as chlorpromazine, hydralazine, penicillin, phenytoin, procainamide, and quinidine

    • Increased Levels:
    • -Systemic Lupus Erythematosus
    • -Antiphospholipid Syndrome
  2. Anti-DNA Antibody
    • NORMAL FINDINGS:
    • -Negative: <70 international units/mL
    • -Borderline: 70-200 international units/mL
    • -Positive: >200 international units/mL

    This test is useful for the diagnosis and follow-up of Systemic Lupus Erythematosus (SLE)

    • Interfering Factors:
    • -A radioactive scan performed within 1 week before the test
    • -Drugs that cause increased levels are hydralazine and procainamide

    • Increased Levels:
    • -Collagen-vascular diseases
    • -Other autoimmune diseases such as RA
    • -Chronic hepatitis
    • -Infectious mononucleosis
    • -Bilary cirrhosis
  3. Anti-ENA (Antiextractable Nuclear Antigen)
    • NORMAL FINDINGS:
    • -Negative

    This test is used to assist the diagnosis of Systemic Lupus Erythematosus (SLE) and mised connective tissue disease (MCTD) and to eliminate other rheumatoid diseases

    • Increased Anti-SM Antibodies Levels:
    • -SLE

    • Increased Anti-RNP Antibodies:
    • -MCTD
    • -SLE
    • -Discoid Lupus Scleroderma
  4. Antinuclear Antibody (ANA)
    • NORMAL FINDINGS:
    • -Negative at 1:40 dilution

    This test is used to diagnose Systemic Lupus Erythematosus and other autoimmune diseases

    • Interfering Factors:
    • -Drugs that can cause a false-positve test include acetazolamide, aminosalicylic acid, chlorothiazides, chlorprothixene, grisefulvin, hydralizine, penicilin, phenylbutazone, phenytoin, procainamide, streptomycin, sulfonamides, and tetracyclines
    • -Drugs that can cause false negative results include steroids

    • Increased Levels:
    • -Systemic Lupus Erythematosus (SLE)
    • -RA
    • -Scleroderma
    • -Sjogrens Syndrome
    • -Raynaud Phenomenon
    • -Leukemia
  5. Complement Assay
    • NORMAL FINDINGS:
    • Total Complement: 75-160 units/mL

    Used primarily to monitor the activity of the disease in patients with Systemic Lupus Erythematosus(SLE)

    • Increased Levels:
    • -MI
    • -Ulcerative Colitis
    • -Cancer
    • -Inflammatory illnesses

    • Decreased Levels:
    • -Hereditary angioedema
    • -Autoimmune Disease: SLE, RA, Sjogren Syndrome
    • -Renal transplant rejection
    • -Malnutrition

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