PHARM 422 AND 423

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Author:
jaguavai
ID:
130818
Filename:
PHARM 422 AND 423
Updated:
2012-01-26 16:18:03
Tags:
Dr Lady
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Description:
Pharm, 422 and 423
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  1. Glucocorticoids come from the zona
    fasciculata
  2. Mineralcorticoids come from the zona
    glomerulosa
  3. Stress > hypothalmus > CRH > ant. pituatary > ACTH > adrenal gland > cortisol
    Good.
  4. Aldosterone does
    Na and fluid retention
  5. Dosing for glucocorticoids(25)
    Hydrocortisone (20)

    • Corsitone (25)
    • Prednisone (5)
    • Prednisolone (5)
    • Methylpred (4)
    • Triamcinolone (4)
    • Betamethasone (0.75)
    • Dexamethasone (0.75)
  6. Adverse effects of clucocorticoids (5)
    • Iatrogenic Cushing's Syndrome
    • Gastric Ulcers
    • Hirsutism
    • Weight gain
    • Edema
  7. Menstrual cycle
    FSH levels rise, recruitment of follicle. On day 7, one becomes dominant. As follicle grows it releases estradiol, causeing endometrium to mature. Estradiol stiumlates pituatary to release LH. 34 hrs after the surge the follicle bursts, forming corpus luteum. CL produces progesterone which maintains the endometrium. If fertilized, hCG will cause progesterone synthesis but if not, progesterone levels from CL decrease causing menses.
  8. DHEA > androstenedione > testosterone OR estrone via aromatose. Estrone can go to estradiol or estriol (pregnancy)
    OK
  9. Estrogen causes a good lipid profile, progesterone causes a bad lipid profile.
    Good work.
  10. Norethindrone is (which drug)
    progestin-only

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