Parkinson

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Author:
capnhue
ID:
130877
Filename:
Parkinson
Updated:
2012-02-12 00:43:50
Tags:
Regis University
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Description:
Parkinson
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  1. Drugs that can cause Parkinson (Antipsychotics)
    • chlorpromazine
    • thioridazine
    • fluphenazine
    • loxapine
    • haloperidol
    • olanzapine
    • risperidone
  2. Drugs that can cause Parkinson (Antiemetics)
    • metoclopramide
    • prochlorperazine
  3. Risk factors that increase risk for Parkinson
    • genetics
    • male
    • pesticide exposure
    • well water (rural areas)
    • head injury
  4. Protective factors reduce risk of Parkinson
    • coffee
    • cigarette smoking
    • NSAIDS
    • estrogen replacement post menopause
  5. Medications associated with tremors
    • lithium
    • valporic acid
    • albuterol
    • theophylline
    • cyclosporine
    • caffeine
    • other stimulants
  6. Treatment for action and essential tremors
    • propranolol
    • primidone
  7. Non motor PD symptoms and treatments
    • Bladder incontinence: oxybutyin, tolterodine
    • Constipation: incrrease water, dietary fiber, polyethylene glycol
    • Olfactory dysfunction (hyposmia): N/A
    • REM sleep behavior disorder: clonazepam, melatonin, dopaminergic medications
    • Depression: TCAs, SSRI
  8. Rasagiline (MAO-B inhibitor) drug-drug interactions
    • CYP1A2 inhibitor: decreases clearance of rasagiline
    • cipro
    • fluvoxamine
    • cimetidine
    • CYP1A2 inducer: increases clearance of rasagiline
    • omeprazole
    • smoking
  9. MAO-B drug-drug interactions
    • MAO-B with tyramine: MAO-B loses its selectivity
    • Serotonin syndrome: interactions w/
    • SSRI
    • SNRI
    • meperidine
    • dextromethorphan
    • decongestants (sympathomimetic meds)
    • non-selective MAO inhibitors
  10. Levodopa drug-drug interactions
    • reduced efficacy of levodopa: interactions w/
    • D2 recptor antagonists (phenothiazines, risperidone, antipsychotics)
    • metoclopramide (antiemetic D2 antagonist
    • phenytoin)
    • Hypertensive crisis: interactions w/ phenelzine, tranycypromine
  11. Pramipexole drug-drug interactions
    • reduced clearance that inhibit cationic tubular secretion: interactions w/
    • cimetidine
    • diltiazem
    • probenecid
    • ranitidine
    • triamterene
    • verapamil
  12. Ropinirole drug-drug interactions
    • clearance is reduced: when estrogen therapy is started
    • CYP1A2 inhibitor: decreases clearance of ropinirole
    • cipro
    • fluvoxamine
    • cimetidine
    • CYP1A2 inducer: increases clearance of ropinirole
    • omeprazole
    • smoking
  13. Apomorphine drug-drug interactions
    • ondansetron: can cause severe hypotension and loss of consciousness and is contraindicated
    • trimethobenzamide: can be used to treat the nasuea/severe emesis associated with apomorphine
  14. Anticholinergic drug-drug interactions
    • may increase the risk of paralytic ileus, hyperthermia, or heat tolerance: interacting w/
    • phenothiazines
    • haloperidol
    • TCAs
    • potassium chloride: this interaction slows the gastric motility delaying the passage of potassium chloride resulting in lesions and ulcerations
  15. Amantadine drug-drug interactions
    • reduces the renal clearance: interacting w/
    • quinine
    • quinidine
    • potassium chloride: this interaction slows the gastric motility delaying the passage of potassium chloride resulting in lesions and ulcerations
  16. Nausea caused by levodopa
    • if currently on levodopa/carbidopa: treat w/
    • carbidopa 25mg addition
  17. Nausea caused by dopamine agonist
    • treat w/:
    • ondansetron
    • trimethobenzamide
    • dronabinol
    • avoid: prochlorperazine, metoclopramide
  18. Neuroleptic Malignant Syndrome (NMS)
    • Caused by the abrupt cessation of levodopa and dopamine agonists
    • NMS symptoms include:
    • elevated temperature (100.4)
    • alter level of consciousness, confusion, tachycardia, diaphoresis, urinary or fecal continence
    • piplike rigidity

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