What is "frustrated phagocytosis" and how does it relate to hypersensitivity reactions?
Frustrated phagocytosis occurs in a Type III response. The medium immune complexes are not big enough to attract phagocytes, but are too big to cross glomerular membrane to be voided out. Therefore, they get stuck in the membrane and since they are too big for the neutrophils to wrap around, the neutrophils release contents to lyse the cell and antigen. This causes tissue damage in that area.