Antimetabolite Agents- interferes with metabolic processes (usually) in the S phase
causing cell death. Mimick nutrients that the cell uses to synthesize DNA, RNA, and proteins. When antimetabolites are used they dont function properly causing disruption of cell function.
- Folic Acid analogs -Methotrexate,
- Purine analogs
- Pyrimidine analogs - 5-fluorouracil
Side Effects: Nausea, vomiting, stomatitis, anorexia, rash, alopecia, headache, bone marrow supression, diarrhea, mucositis, hepatotoxicity, pulmonary toxicity, neurotoxicity, anaphylaxis