Exam 1

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leo25
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131502
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Exam 1
Updated:
2012-02-01 00:38:51
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Pathophysiology
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Ch.1-3
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  1. What is pathology?
    the study of structural alterations in cells, tissues and organs which help to identify the cause of disease
  2. What is pathogenesis?
    the pattern of tissue changes associated with the development of a disease
  3. What is etiology?
    the study of the cause of disease and/or injury
  4. What does idiopathic mean?
    disease has no identifiable cause
  5. What does iatrogenic mean?
    disease and/or injury as a result of medical intervention

    "iatro"= physician
  6. What does nosocomial mean?
    a disease is acquired as a result of being in a hospital environment
  7. What is remission?
    a period when clinical manifestations disappear or diminish significantly
  8. What is exacerbation?
    a period when clinical manifestations become worse or more severe (relapse)
  9. What is sequela(e)?
    any abnormal condition that follows and is the result of a disease, treatment or injury

    ex: change in HR after a bleed
  10. What structure is mostly RNA, most of the cellular DNA, DNA-binding proteins, and histones?
    nucleolus
  11. What binds to DNA for folding into chromosomes?
    histones
  12. What are RNA-protein complexes and sites of protein synthesis?
    ribosomes
  13. What is responsible for protein synthesis, and contains ribophorins that are docking molecules for ribosomes on the ER?
    Rough ER
  14. What contains enzymes for steroid hormone synthesis and for removing toxins from the cell?
    Smooth ER
  15. What packages proteins fro the ER into secretory vesicles?
    Golgi apparatus
  16. What is clathrin?
    a protein that coats vesicles
  17. What structures bud from the Golgi complex on the outward secretory pathway?
    clathrin-coated vesicles
  18. What structures originate from the Golgi and contain more than 40 hydrolases for intracellular digestion?
    lysosomes
  19. When do the enzymes in lysosomes become active?
    when the pH is lowered (more H+ ions are pumped in)
  20. What is the difference between a primary lysosome and a secondary lysosome?
    • primary= in holding pattern (inactive)
    • secondary= when primary fuses with a vacuole or other organelle, the pH drops and the enzymes are activated
  21. What are structures similar to lysosomes, but larger, oval and/or irregular in shape?
    peroxisomes
  22. How do lysosomes and peroxisomes differ?
    • peroxisomes contain oxidative enzymes like catalase and urate oxidase
    • peroxisomes may be able to kill bacteria that lysosomes cannot by making superoxide, hydrogen peroxide, or hydroxyl ions
  23. What structures are found in many vertebrate species, are most abundant in macrophages and epithelial cells, and are found on leading lamellapodia and at adhesion plaques, as well as on ends of actin filaments?
    vaults
  24. What structure has 4 components: 3 protein and 1 RNA and is the largest cytoplasmic ribonucleoprotein known?
    vault
  25. What structures have been proposed to be a component of the nuclear pore complex (NPC) known as the central plug or NPC transporter?
    vault
  26. What is the gelatinous, semiliquid portion of the cytoplasm that functions in intermediary metabolism, ribosomal protein synthesis, and storage of excess nutrients like glycogen?
    cytosol
  27. What is the proposed hypothesis for the role of vault's in disease?
    may play a role in cancer cells' resistance to drug therapy
  28. define hypertrophy
    increase in cell size
  29. define hyperplasia
    increase in cell #
  30. define metaplasia
    reversible replacement of one mature cell type with a less mature cell type
  31. define dysplasia
    • deranged cell growth
    • not adaptation
  32. what are the different types of adaptation in cells?
    • atrophy
    • hyperplasia
    • hypertrophy
    • metaplasia
    • kind of dysplasia but not really
  33. What is the normal range of sodium in the body?
    142 mEq/L
  34. What is the normal range of chloride in the body?
    95-105 mEq/L
  35. What is the normal range of calcium in the body?
    8.8-10.5 mEq/L
  36. What is the normal range of potassium in the body?
    3.5-5 mEq/L
  37. What is normal blood pH?
    7.35-7.45
  38. What is the typical carbon dioxide content in the blood (arteries)?
    35-45 mm Hg
  39. What is the typical oxygen content in the blood (arteries)?
    75-100 mm Hg
  40. What is the normal amount of bicarbonate in the blood?
    24-28 mEq/L
  41. Does plasma contain clotting factors?
    yes
  42. Does serum contain clotting factors?
    no
  43. Which portion of fluids in our body constitutes 2/3?
    ICF
  44. Which portion of fluids in our body constitutes 1/3?
    ECF
  45. What are the 4 main components of the ECF?
    • interstitial fluid (between cells)
    • intravascular (blood plasma)
    • trans-cellular (sweat, urine, CSF, intraocular, pancreatic, biliary, intestinal, hepatic, plural, synovial)
    • lymph
  46. What % of our body is water?
    • ~60%
    • about 42 liters
  47. What provides a fixed source of osmotic force/pressure in our bodies?
    intracellular proteins
  48. Which ion is responsible for osmotic balance of the ECF?
    sodium
  49. Which ion is responsible for the osmotic balance of the ICF?
    potassium
  50. What are the forces that favor filtration?
    capillary hydrostatic pressure and interstitial oncotic pressure
  51. What are the forces the oppose filtration?
    plasma oncotic pressure and interstitial hydrostatic pressure
  52. Which has a higher net filtration pressure-- arteriole or venous capillaries?
    arteriole
  53. What happens when filtration > reabsorption?
    edema
  54. What are the 4 most common causes of edema?
    • increased hydrostatic pressure
    • lymph obstruction
    • decreased plasma oncotic pressure
    • increased capillary permeability
  55. What are some causes of increased hydrostatic pressure (that would lead to edema)?
    • congestive heart failure
    • renal failure
    • prolonged standing
    • thrombosis
    • salt and water retention
  56. What are some causes of decreased oncotic plasma pressure (that would lead to edema)?
    • hemorrhage
    • burns
    • cirrhosis
    • liver disease
    • protein malnutrition
    • (all lead to decrease in proteins in plasma)
  57. What are some causes of increased capillary permeability (that would lead to edema)?
    • injury or trauma
    • burns
    • cancerous growths
    • crushed
    • allergic reactions
  58. which ion makes up the majority of ECF?
    sodium
  59. which ion makes up the majority of ICF?
    potassium
  60. How do we regulate water balance?
    • thirst
    • ADH
  61. How do we regualate salt (sodium) balance?
    • aldosterone (from adrenal cortex)-acts on kidneys
    • -------renin, angiotensin, aldosterone
    • ANP
  62. What hormone causes a decrease in BP and a decrease in circulating blood if osmolality goes up(excess plasma sodium) or there is a loss of water?
    ADH
  63. What triggers the release of renin?
    • decreased blood pressure or volume
    • or decreased perfusion of renal vessels
  64. What is the major net effect of renin?
    increase blood pressure
  65. What is an example of an ectoenzyme that is in the RAA system?
    • ACE
    • Ang I is converted in the lung
  66. Where is renin stored and released?
    in the juxtaglomerular complex in the afferent arterioles (kidney)
  67. What does Ang II do?
    • stimulates aldosterone release from adrenal cortex
    • growth factor in heart and blood vessels
    • stimulates sodium reabsorption in the kidney so that it can go back into the blood
    • stimulates Na/K ATPase pump in basolateral membrane
    • stimulates Na/H exchange in luminal membrane
  68. What factors stimulate renin release?
    • hypotension
    • dehydration
    • diuretics
    • sodium depletion
    • cardiac failure
    • upright position
  69. When is ANP released?
    when the BP increases or the ECF increases
  70. What hormone inhibits ADH?
    ANP
  71. How does ANP lower BP and increase sodium excretion?
    • increases capillary permeability
    • increasing GFR
  72. If the ECF is hypertonic,what happens to RBCs?
    they shrink
  73. If the ECF is hypotonic, what happens to RBCs?
    they swell
  74. What are the S&S of isotonic loss?
    • contraction of ECF volume
    • weight loss
    • decreased urine
    • dry skin/mm
    • hypovolemia
    • increased HR
    • decreased BP
    • postural hypotension
    • flat neck veins
  75. What are the S&S of isotonic gain?
    • hypervolemia
    • weight gain
    • increased BP
    • decreased hematocrit b/c of dilution
    • decreased plasma proteins b/c of dilution
    • extended neck veins
    • pulmonary edema
    • heart failure
  76. What can cause isotonic gain?
    • cortisone (drugs)
    • excessive IV fluids
    • excessive aldosterone (retain water and salt)
  77. If hypertonia is caused by excess sodium in ECF, what are the symptoms?
    like hypervolemia
  78. If hypertonia is caused by a decrease in ECF free water, what are the symptoms?
    like hypovolemia
  79. What lab value would indicate hypernatremia?
    >147 mEq/L
  80. Do high amounts of dietary sodium usually cause hypernatremia?
    no
  81. What are some causes of hypernatremia?
    • not enough water intake
    • primary hyperaldosteronism (oversecret of aldost)
    • Cushing's b/c oversecrete ACTH which stims aldosterone
    • excessive saline IV
    • fever
    • respiratory infections
    • diabetes
    • polyuria
    • diarrhea
  82. What are the S&S of hypernatremia?
    • thirst
    • dry mm
    • fever
    • hypotension
    • tachycardia
    • restlessness
    • low jug BP
  83. What are the S&S of hyperchloremia?
    there are none
  84. What two things is hyperchloremia usually associated with?
    • hypernatremia
    • deficit of bicarbonate in metabolic acidosis
  85. How do you treat dehydration?
    D5W
  86. What are the 2 most common causes of hypotonic alterations?
    • hyponatremia
    • excess water intake (intoxication)
  87. What can insulin be used to treat? (acid base balance disease)
    hyperkalemia

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