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HUSOP2014
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Lovenox
- Gen: Enoxaparin Sodium
- Class: Anticoagulant (LMW-heparin)
- RoA: IV
- MOA: Anti-Factor Xa and anti-thrombin (Factor IIa) activity
- Indication: DVT, PE, MI, Ischemia, (all postop and prohhylaxis)
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Aranesp
- Gen: Darbepoetin Alfa
- Class: Erythropoietic- Hematopoietic
- RoA: IV or SC
- MOA: binds progenitor stem cells stimulating production/differentiation of erthropoiesis
- Indication: Anemia from Chronic kidney disease and Chemotherapy
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Procrit
- Gen: Epoetin Alfa
- Class: Erythropoietic- Hematopoietic
- RoA: IV or SC
- MOA: bone marrow division/differentiation of committed erythroid progenitors
- Indication: Anemia from Chronic renal failure, Chemotherapy, or Surgical procedures
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Revlimid
- Gen: Lenalidomide
- Class: Immune Modulator (antiangiogenetic)
- RoA: Oral
- MOA: inhibits cell proliferation, pro-inflammatory cytokines,
- Indication: Multiple myeloma, Myelodysplastic syndrome
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Neulasta
- Gen: Pegfilgrastim
- Class: Colony Stimulating Factor (CSF), Hematopoetic
- RoA: SC
- MOA: A CSF- stimulates proliferation/differentiation/ activation of hematopoietic cells
- Indication: Febrile neutropenia, in pt with non-myeloid malignancies, Prophylaxis
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Remicade
- Gen: Infliximab
- Class: Immunological agent (TNFa-I)
- RoA: IV infusion
- MOA: inhibits the binding of TNF alpha
- Indication: Crohn's, Colitis, RA, psoriasis
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Rituxan
- Gen: Rituximab
- Class: Antineoplastic agent, (Mab)
- RoA: IV infusion
- MOA: binds to CD20 antigen located on pre-B lymphocytes and may promote lysis
- Indication: Lymphomas, Leukemias, RA
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Levaquin
- Gen: Levofloxacin
- Class: Antibiotic (fluoroquinolone)
- RoA: Oral , IV, optical
- MOA: inhibits topoisomerase IV, DNA gyrase (replication, transcription, repair, recombination)
- Indication: Bronchitis, nosocomial/comm-acquired pneumonia, UTI
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Avastin
- Gen: Bevacizumab
- Class: Immunological Agent, (Mab) VEGF-I
- RoA: IV infusion
- MOA: recombinant humanized monoclonal IgG1 antibody Binds to VEGF to inhibit VEGF/Flt1 & KDR interaction of epithelial cells to prevent new blood vessels
- Indication: Glioblastoma, Cancer (Colorectal, Renal cell Small cell lung)
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Zosyn
- Gen: Piperacillin Sodium/Tazobactam Sodium
- Class: Antibiotic(antipseudomonal/B-lactamase-I)
- RoA: IV infusion
- MOA: Transpeptidase Inhibitor/ B-lactamase-I
- Indication: Appendicitis, Pneumonia, Skin infection, Peritonitis, Puerperal endometritis
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Neupogen
- Gen: Filgrastim
- Class: Colony Stimulating Factor, Hematopoetic
- RoA: SC
- MOA: granulocyte CSF, regulates neutrophil production, progenitor proliferation, and differentiation
- Indication: Febrile neutropenia, harvesting peripheral stem cells
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Eloxatin
- Gen: Oxaliplatin
- Class: Antineoplastic Agent
- RoA: IV
- MOA: undergoes monoenzymatic conversion
- Indication: Colon cancer – stage III, colorectal cancer
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Diprivan
- Gen: Propofol
- Class: Anesthetic, Sedative/hypnotic
- RoA: IV
- MOA: unknown
- Indication: General anesthesia, Sedation for mechanically ventilated (ICU)
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Omnipaque
- Gen: IOHEXOL
- Class: 2nd gen Nonionic Radiocontrast Agent
- RoA: IV
- MOA: low-osmolality intravascular contrast agents
- Indication: Diagnostic- radiography
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Integrilin
- Gen: Eptifibatide
- Class: Anticoagulant, Glycoprotein-I,
- RoA: IV
- MOA: inhibits platelet aggregation by binding to GP2b/3a à prevents binding of fibrinogen, vWf, and other adhesive ligand
- Indication: Acute coronary syndrome, percutaneous coronary intervention
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Advair Diskus
- Gen: Fluticasone Propionate/Salmeterol Xinafoate
- Class: Antiasthma, Anti-inflam/Bronchodilator Combo
- RoA: Inhalation
- MOA: Fluticasone – a glucocorticoid receptor agonist. Salmeterol – long acting beta agonist, relaxes bronchial smooth muscles
- Indication: Asthma, COPD
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Sodium Chloride
- Gen: Sodium Chloride
- Class: Dermatological Agent, Parenteral Electrolyte
- RoA: Inj, IV, Irrigation, Nasal, Ophthalmic, Oral, Topical
- MOA: principle cation of extracellular fluid
- Indication: Corneal edema, Heat stroke, Hyponatremia, Hypovolemic shock, Nasal irritation
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Herceptin
- Gen: Trastuzumab
- Class: Immunological agent, (Mab) HER2-I
- RoA: IV
- MOA: monoclonal antibody binds to HER2 protein to inhibit the growth of tumor cells
- Indication: Metastatic breast cancer, HER2 overexpression
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Zyvox
- Gen: Linezolid
- Class: Antibiotic (RNA-I), Oxazolidinone
- RoA: IV
- MOA: inhibits ribosomal translation by binding to 23S of 50S RNA
- Indication: Pneumonia, Vanco-resistant Enterococcus faecium infection, infection of skin
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Protonix
- Gen: Pantoprazole Sodium
- Class: PPI
- RoA: Oral, IV
- MOA: inhibits acid secretion by covalently binding the H/K ATPase pump
- Indication: GERD, Zollinger-Ellison Syndrome, Gastric hypersecretion
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