Top 50 Hospital drugs.txt

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Top 50 Hospital drugs.txt
2012-02-13 16:41:25
HUSOP Top 50 Hospital Drugs

Brand to Generic, with Class, RoA, MOA, and Indication
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  1. Lovenox
    • Gen: Enoxaparin Sodium,
    • Class: Anticoagulant (LMW-heparin),
    • RoA: IV,
    • MOA: Anti-Factor Xa and anti-thrombin (Factor IIa) activity,
    • Indication: DVT, PE, MI, Ischemia, (all postop and prophylaxis)
  2. Aranesp
    • Gen: Darbepoetin Alfa,
    • Class: Erythropoietic- Hematopoietic,
    • RoA: IV or SC,
    • MOA: stilmulates progenitor stem cells for production/differentiation of erythropoiesis,
    • Indication: Anemia from Chronic Kidney Disease and Chemotherapy
  3. Procrit
    • Gen: Epoetin Alfa,
    • Class: Erythropoietic- Hematopoietic,
    • RoA: IV or SC,
    • MOA: stimulates bone marrow division/differentiation of committed erythroid progenitors,
    • Indication: Anemia from Chronic renal failure, Chemotherapy, or Surgical procedures
  4. Revlimid
    • Gen: Lenalidomide,
    • Class: Immune Modulator (antiangiogenetic),
    • RoA: Oral,
    • MOA: inhibits cell proliferation, pro-inflammatory cytokines,
    • Indication: Multiple myeloma, Myelodysplastic syndrome
  5. Neulasta
    • Gen: Pegfilgrastim,
    • Class: Colony Stimulating Factor(CSF), Hematopoietic,
    • RoA: SC,
    • MOA: A CSF- stimulates proliferation/differentiation/ activation of hematopoietic cells,
    • Indication: Febrile neutropenia, in pt with non-myeloid malignancies, Prophylaxis
  6. Remicade
    • Gen: Infliximab,
    • Class: Immunosuppressant (TNFa-I),
    • RoA: IV infusion,
    • MOA: inhibits the binding of TNF alpha,
    • Indication: Crohn's, Colitis, RA, psoriasis
  7. Rituxan
    • Gen: Rituximab,
    • Class: Antineoplastic agent, (Murine-Mab),
    • RoA: IV infusion,
    • MOA: binds to CD20 antigen located on pre-B lymphocytes and may promote lysis,
    • Indication: Lymphomas, Leukemias, RA
  8. Levaquin
    • Gen: Levofloxacin,
    • Class: Antibiotic (fluoroquinolone),
    • RoA: Oral , IV, optical,
    • MOA: inhibits topoisomerase IV, DNA gyrase (replication, transcription, repair, recombination),
    • Indication: Bronchitis, Pneumonia, UTI, (Anthrax)
  9. Avastin
    • Gen: Bevacizumab,
    • Class: Immunomodulator, Antiangiogentic, (Mab) VEGF-I,
    • RoA: IV infusion,
    • MOA: IgG1 antibody Binds to VEGF to inhibit VEGF/Flt1 & KDR interaction of epithelial cells
    • Indication: Glioblastoma, Cancer (Colorectal, Renal cell Small cell lung)
  10. Zosyn
    • Gen: Piperacillin Sodium/Tazobactam Sodium,
    • Class: Antibiotic (antipseudomonal/B-lactamase-I),
    • RoA: IV infusion,
    • MOA: Transpeptidase-I/ B-lactamase-I ,
    • Indication: Appendicitis, Pneumonia, Skin infection, Peritonitis, Puerperal endometritis
  11. Neupogen
    • Gen: Filgrastim,
    • Class: Colony Stimulating Factor, Hematopoietic,
    • RoA: SC,
    • MOA: granulocyte CSF, regulates neutrophil production, progenitor proliferation, and differentiation,
    • Indication: Febrile neutropenia, harvesting peripheral stem cells
  12. Eloxatin
    • Gen: Oxaliplatin,
    • Class: Antineoplastic Agent, Platinum Coordinating Complex
    • RoA: IV,
    • MOA: binds nucleotides to inhibit DNA replication of tumor cells
    • Indication: Colon cancer - stage III, colorectal cancer
  13. Diprivan
    • Gen: Propofol,
    • Class: Sedative/Hypnotic, Anesthetic,
    • RoA: IV,
    • MOA: unknown,
    • Indication: General anesthesia, Sedation for mechanically ventilated
  14. Omnipaque
    • Gen: Iohexol,
    • Class: (dye)Non-Ionic Contrast Agent,
    • RoA: IV,
    • MOA: hypotonic, low osmolality to serum,
    • Indication: Diagnostics radiology
  15. Integrilin
    • Gen: Eptifibatide,
    • Class: Anticoagulant, Glycoprotein-I (2b/3a)
    • RoA: IV,
    • MOA: inhibits platelet aggregation by binding to GP2b/3a - prevents binding of fibrinogen, vWf, and other adhesive ligand,
    • Indication: Acute coronary syndrome, percutaneous coronary intervention
  16. Advair Diskus
    • Gen: Fluticasone Propionate/Salmeterol Xinafoate,
    • Class: Antiasthma, Anti-inflam/Bronchodilator Combo,
    • RoA: Inhalation,
    • MOA: Fluticasone: glucocorticoid receptor agonist. Salmeterol: long acting beta agonist, relaxes bronchial smooth muscles,
    • Indication: Asthma, COPD
  17. Sodium Chloride
    • Gen: Sodium Chloride,
    • Class: Dermatological Agent, Parenteral Electrolyte, Sodium Supplement,
    • RoA: Inj, IV, Topical,
    • MOA: principle cation of extracellular fluid,
    • Indication: Hyponatremia, Hypovolemic shock, Nasal irritation
  18. Zyvox
    • Gen: Linezolid,
    • Class: Antibiotic (Oxazolidinone),
    • RoA: IV
    • MOA: inhibits ribosomal translation by binding to 23S of 50S RNA, Preventing 70S complex formation
    • Indication: Pneumonia, Vanco-resistant Enterococcus faecium infection, infection of skin
  19. Herceptin
    • Gen: Trastuzumab,
    • Class: Antineoplastic Agent, Mab (HER2-I),
    • RoA: IV,
    • MOA: Mab binds to HER2 protein to inhibit the growth of tumor cells,
    • Indication: Metastatic breast cancer, HER2 overexpression
  20. Protonix
    • Gen: Pantoprazole Sodium,
    • Class: PPI,
    • RoA: Oral, IV
    • MOA: inhibits acid secretion by covalently binding to the H/K ATPase pump,
    • Indication: GERD, Zollinger-Ellison Syndrome, Gastric hypersecretion
  21. Taxotere
    • Gen: Docetaxel,
    • Class: Antineoplastic Agent (Mitotic-I),
    • RoA: IV,
    • MOA: binds/inhibits microtubule disassembly inhibiting mitotic/interphase = no cell division,
    • Indication: Breast cancer, Gastric cancer, Head & neck cancer, hormone refractory prostate cancer, lung cancer
  22. Angiomax
    • Gen: Bivalirudin,
    • Class: Anticoagulant, Hirudin related, Thrombin-I,
    • RoA: IV,
    • MOA: binds to catalytic site and the anion-binding exosite of circulating and clot-bound thrombin,
    • Indication: Heparin-induced thrombocytopenia, Thromboembolic disorder
  23. Thrombin-jmi
    • Gen: Bovine Thrombin,
    • Class: Hemostatic, Coagulant,
    • RoA: Topical,
    • MOA: a protein substance that immediately clots the fibrinogen of the blood,
    • Indication: hemorrhage
  24. Cancidas
    • Gen: Caspofungin Acetate,
    • Class: Antifungal, Echinocandin, Glucan Synthesis I,
    • RoA: IV,
    • MOA: inhibits beta-1,3-D-glucan synthesis: an important component of cell wall,
    • Indication: Aspergillosis, Candidemia, Febrile neutropenia
  25. Ultane
    • Gen: Sevoflurane,
    • Class: Anesthetic, Haloalkane,
    • RoA: Inhalation,
    • MOA: disrupts lipid matrix of neuronal membranes affecting gating of ion channels,
    • Indication: General Anesthesia
  26. Seroquel
    • Gen: Quetiapine Fumarate,
    • Class: Antipsychotic, Dibenzothiazepine,
    • RoA: Oral,
    • MOA: antagonist of 5-HT1A, 2, D1,2, H1, and alpha1,2,
    • Indication: Bipolar-1, MDD, Schizophrenia
  27. Protonix IV
    • Gen: Pantoprazole Sodium,
    • Class: PPI,
    • RoA: Oral, IV
    • MOA: inhibits acid secretion by covalently binding to the H/K ATPase pump,
    • Indication: GERD, Zollinger-Ellison Syndrome, Gastric hypersecretion
  28. Gemzar
    • Gen: Gemcitabine Hydrochloride,
    • Class: Antineoplastic Agent, Antimetabolite
    • RoA: IV,
    • MOA: nucleoside analogue cell phase-specific for the S-phase and for the G1/S-phase, inhibits DNA synthesis,
    • Indication: Breast, Ovarian, Pancreas, non-small cell lung cancers
  29. Erbitux
    • Gen: Cetuximab,
    • Class: Antineoplastic agent, (Mab) EGFR-I,
    • RoA: IV,
    • MOA: binds EGFR blocking phosphorylation/activation of kinases, inhibiting growth/survival of tumor cells
    • Indication: Cancers (Head, neck, colorectal)
  30. Visipaque
    • Gen: Iodixanol,
    • Class: (Dye)Non-Ionic Contrast Agent
    • RoA: IV,
    • MOA: hypotonic, low osmolality to serum,
    • Indication: Diagnostics Radiography
  31. Primaxin
    • Gen: Imipenem/Cilastatin,
    • Class: Antibiotic (Carbapenem),
    • RoA: IV > IM,
    • MOA: B-lactam-I/dipeptidase-I(to stop rapid metabolizing of imipenem),
    • Indication: Infections (LRT, UTI, abdominal, skin, bone, endocarditis, sepsis)
  32. Zocor
    • Gen: Simvastatin,
    • Class: Antihyperlipidemic, Statin (HMG-CoA-I),
    • RoA: Oral,
    • MOA: HMG-CoA reductase inhibitor,
    • Indication: hypercholesterolemia (CHD, diabetes, stroke, MI)
  33. Ms Contin
    • Gen: Morphine Sulfate,
    • Class: Opiate Analgesic,
    • RoA: Oral,
    • MOA: CNS mu opioid receptor agonist,
    • Indication: Moderate to severe 24 hr pain management
  34. Vancocin
    • Gen: Vancomycin Hydrochloride,
    • Class: Antibiotic (glycopeptide),
    • RoA: IV, oral,
    • MOA: Blocks protein synthesis (blocks initiation, elicits premature termination, or incorporates incorrect AA),
    • Indication: Methicillin-resistant staph, endocarditis
  35. Nexium
    • Gen: Esomeprazole,
    • Class: PPI,
    • RoA: Oral,
    • MOA: inhibits acid secretion by covalently bonding the H/K ATPase pump,
    • Indication: Erosive esophagitis, GERD, NSAID-GU, H.pylori-DU, Zollinger-Ellison Syndrome
  36. Plavix
    • Gen: Clopidogrel Hydrogen Sulfate,
    • Class: Anti-coagulant, ADP-Induced AC
    • RoA: Oral,
    • MOA: Irreversibly binds to ADP-P2Y12 receptors on platelets to inhibit GPIIb/IIIa complex,
    • Indication: MI, Stroke, Peripheral arterial disease
  37. Zometa
    • Gen: Zoledronic Acid,
    • Class: Bisphosphonate, Calcium Regulator,
    • RoA: IV infusion,
    • MOA: inhibits osteoclasts to lower calcium release,
    • Indication: Hypercalcemia of Malignancy, Multiple Myeloma, Bone Metastases
  38. Gamunex
    • Gen: Immune Globulin,
    • Class: Immune Globulin-IgG,
    • RoA: IV,
    • MOA: supplies IgG antibodies, blockade of Fc receptor on macrophages
    • Indication: Primary Humoral Immunodeficiency (PI), Idiopathic Thrombocytopenia Purpura (ITP), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
  39. Camptosar
    • Gen: Irinotecan Hydrochloride,
    • Class: Anti-Neoplastic Agent, Topoisomerase1-I,
    • RoA: IV infusion,
    • MOA: binds topoisomerase-1 DNA complex,
    • Indication: colon/rectum metastic carcinoma
  40. Risperdal
    • Gen: Risperidone,
    • Class: Antipsychotic (Benzisoxazole)
    • RoA: Oral, IM,
    • MOA: D2 and 5HT2 antagonists,
    • Indication: Schizophrenia, Bipolar,
  41. Zyprexa
    • Gen: Olanzapine,
    • Class: Antipsychotic (Thienobenzadiazepine),
    • RoA: Oral, IM,
    • MOA: D2, 5HT2 antagonist,
    • Indication: Schizophrenia, Bipolar
  42. Lupron Depot
    • Gen: Leuprolide Acetate,
    • Class: Antineoplastic Agent, LHRH Agonist,
    • RoA: IV, IM, ID, SC,
    • MOA: Gonadotropin-releasing Hormone (GnRH), Luteinizing H-Releasing H,
    • Indication: Anemia, Endometriosis, Prostate cancer
  43. Prevacid
    • Gen: Lansoprazole,
    • Class: PPI,
    • RoA: Oral,
    • MOA: inhibits acid secretion by covalently binding the H/K ATPase pump,
    • Indication: DU, GERD, NSAID-GU, Zollinger-Ellison syndrome
  44. Zithromax
    • Gen: Azithromycin,
    • Class: Antibiotic (macrolide),
    • RoA: Oral,
    • MOA: binds 50-S ribosomal subunit (interferes with microbial protein synthesis),
    • Indication: COPD, otitis media, conjunctivitis, pneumonia, gonorrhea (bacterial infections)
  45. Lipitor
    • Gen: Atorvastatin,
    • Class: Antihyperlipidemic, HMG-CoA reductase-I (statin)
    • RoA: Oral,
    • MOA: inhibits cholesterol synthesis, increases LDL receptors,
    • Indication: Hypercholesterolemia, hyperglyceridemia, Familial type-3 hyperlipoproteinemia, CVD (prophylaxis), type 2 diabetes mellitus
  46. Cubicin
    • Gen: Daptomycin,
    • Class: Antibiotic, Lipopeptide,
    • RoA: IV,
    • MOA: binds cell membrane depolarizing membrane potential leading to disrupt DNA, RNA and protein synthesis,
    • Indication: Bacteremia, endocarditis, staph aureus
  47. Suprane
    • Gen: Desflurane,
    • Class: Haloalkane, Anesthetic,
    • RoA: Inhalation,
    • MOA: increase GABA transmission, disrupts lipid matrix of neuronal membranes affecting gating of ion channels,
    • Indication: General anesthesia
  48. Cardene I.V.
    • Gen: Nicardipine,
    • Class: Anti-HT, CCBlocker,
    • RoA: IV, oral,
    • MOA: blocks the transmembrane influx of Ca+ affecting cardiac/SM contractility,
    • Indication: HT, postoperative HT, Stable angina
  49. Adenoscan
    • Gen: Adenosine,
    • Class: Adenosine R-agonist, Antiarrhythmic,
    • RoA: IV,
    • MOA: slows impulse formation SA node, and conduction of AV node (influence cellular Ca dynamics),
    • Indication: Paroxysmal supraventricular tachycardia
  50. Synagis
    • Gen: Palivizumab,
    • Class: Immunological/antiviral, (Mab) RSV-I,
    • RoA: IM,
    • MOA: exhibits neutralizing and fusion-inhibitory activity,
    • Indication: Respiratory syncytial virus infection (RSV)