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Lovenox
- Gen: Enoxaparin Sodium,
- Class: Anticoagulant (LMW-heparin),
- RoA: IV,
- MOA: Anti-Factor Xa and anti-thrombin (Factor IIa) activity,
- Indication: DVT, PE, MI, Ischemia, (all postop and prophylaxis)
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Aranesp
- Gen: Darbepoetin Alfa,
- Class: Erythropoietic- Hematopoietic,
- RoA: IV or SC,
- MOA: stilmulates progenitor stem cells for production/differentiation of erythropoiesis,
- Indication: Anemia from Chronic Kidney Disease and Chemotherapy
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Procrit
- Gen: Epoetin Alfa,
- Class: Erythropoietic- Hematopoietic,
- RoA: IV or SC,
- MOA: stimulates bone marrow division/differentiation of committed erythroid progenitors,
- Indication: Anemia from Chronic renal failure, Chemotherapy, or Surgical procedures
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Revlimid
- Gen: Lenalidomide,
- Class: Immune Modulator (antiangiogenetic),
- RoA: Oral,
- MOA: inhibits cell proliferation, pro-inflammatory cytokines,
- Indication: Multiple myeloma, Myelodysplastic syndrome
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Neulasta
- Gen: Pegfilgrastim,
- Class: Colony Stimulating Factor(CSF), Hematopoietic,
- RoA: SC,
- MOA: A CSF- stimulates proliferation/differentiation/ activation of hematopoietic cells,
- Indication: Febrile neutropenia, in pt with non-myeloid malignancies, Prophylaxis
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Remicade
- Gen: Infliximab,
- Class: Immunosuppressant (TNFa-I),
- RoA: IV infusion,
- MOA: inhibits the binding of TNF alpha,
- Indication: Crohn's, Colitis, RA, psoriasis
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Rituxan
- Gen: Rituximab,
- Class: Antineoplastic agent, (Murine-Mab),
- RoA: IV infusion,
- MOA: binds to CD20 antigen located on pre-B lymphocytes and may promote lysis,
- Indication: Lymphomas, Leukemias, RA
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Levaquin
- Gen: Levofloxacin,
- Class: Antibiotic (fluoroquinolone),
- RoA: Oral , IV, optical,
- MOA: inhibits topoisomerase IV, DNA gyrase (replication, transcription, repair, recombination),
- Indication: Bronchitis, Pneumonia, UTI, (Anthrax)
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Avastin
- Gen: Bevacizumab,
- Class: Immunomodulator, Antiangiogentic, (Mab) VEGF-I,
- RoA: IV infusion,
- MOA: IgG1 antibody Binds to VEGF to inhibit VEGF/Flt1 & KDR interaction of epithelial cells
- Indication: Glioblastoma, Cancer (Colorectal, Renal cell Small cell lung)
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Zosyn
- Gen: Piperacillin Sodium/Tazobactam Sodium,
- Class: Antibiotic (antipseudomonal/B-lactamase-I),
- RoA: IV infusion,
- MOA: Transpeptidase-I/ B-lactamase-I ,
- Indication: Appendicitis, Pneumonia, Skin infection, Peritonitis, Puerperal endometritis
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Neupogen
- Gen: Filgrastim,
- Class: Colony Stimulating Factor, Hematopoietic,
- RoA: SC,
- MOA: granulocyte CSF, regulates neutrophil production, progenitor proliferation, and differentiation,
- Indication: Febrile neutropenia, harvesting peripheral stem cells
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Eloxatin
- Gen: Oxaliplatin,
- Class: Antineoplastic Agent, Platinum Coordinating Complex
- RoA: IV,
- MOA: binds nucleotides to inhibit DNA replication of tumor cells
- Indication: Colon cancer - stage III, colorectal cancer
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Diprivan
- Gen: Propofol,
- Class: Sedative/Hypnotic, Anesthetic,
- RoA: IV,
- MOA: unknown,
- Indication: General anesthesia, Sedation for mechanically ventilated
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Omnipaque
- Gen: Iohexol,
- Class: (dye)Non-Ionic Contrast Agent,
- RoA: IV,
- MOA: hypotonic, low osmolality to serum,
- Indication: Diagnostics radiology
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Integrilin
- Gen: Eptifibatide,
- Class: Anticoagulant, Glycoprotein-I (2b/3a)
- RoA: IV,
- MOA: inhibits platelet aggregation by binding to GP2b/3a - prevents binding of fibrinogen, vWf, and other adhesive ligand,
- Indication: Acute coronary syndrome, percutaneous coronary intervention
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Advair Diskus
- Gen: Fluticasone Propionate/Salmeterol Xinafoate,
- Class: Antiasthma, Anti-inflam/Bronchodilator Combo,
- RoA: Inhalation,
- MOA: Fluticasone: glucocorticoid receptor agonist. Salmeterol: long acting beta agonist, relaxes bronchial smooth muscles,
- Indication: Asthma, COPD
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Sodium Chloride
- Gen: Sodium Chloride,
- Class: Dermatological Agent, Parenteral Electrolyte, Sodium Supplement,
- RoA: Inj, IV, Topical,
- MOA: principle cation of extracellular fluid,
- Indication: Hyponatremia, Hypovolemic shock, Nasal irritation
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Zyvox
- Gen: Linezolid,
- Class: Antibiotic (Oxazolidinone),
- RoA: IV
- MOA: inhibits ribosomal translation by binding to 23S of 50S RNA, Preventing 70S complex formation
- Indication: Pneumonia, Vanco-resistant Enterococcus faecium infection, infection of skin
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Herceptin
- Gen: Trastuzumab,
- Class: Antineoplastic Agent, Mab (HER2-I),
- RoA: IV,
- MOA: Mab binds to HER2 protein to inhibit the growth of tumor cells,
- Indication: Metastatic breast cancer, HER2 overexpression
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Protonix
- Gen: Pantoprazole Sodium,
- Class: PPI,
- RoA: Oral, IV
- MOA: inhibits acid secretion by covalently binding to the H/K ATPase pump,
- Indication: GERD, Zollinger-Ellison Syndrome, Gastric hypersecretion
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Taxotere
- Gen: Docetaxel,
- Class: Antineoplastic Agent (Mitotic-I),
- RoA: IV,
- MOA: binds/inhibits microtubule disassembly inhibiting mitotic/interphase = no cell division,
- Indication: Breast cancer, Gastric cancer, Head & neck cancer, hormone refractory prostate cancer, lung cancer
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Angiomax
- Gen: Bivalirudin,
- Class: Anticoagulant, Hirudin related, Thrombin-I,
- RoA: IV,
- MOA: binds to catalytic site and the anion-binding exosite of circulating and clot-bound thrombin,
- Indication: Heparin-induced thrombocytopenia, Thromboembolic disorder
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Thrombin-jmi
- Gen: Bovine Thrombin,
- Class: Hemostatic, Coagulant,
- RoA: Topical,
- MOA: a protein substance that immediately clots the fibrinogen of the blood,
- Indication: hemorrhage
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Cancidas
- Gen: Caspofungin Acetate,
- Class: Antifungal, Echinocandin, Glucan Synthesis I,
- RoA: IV,
- MOA: inhibits beta-1,3-D-glucan synthesis: an important component of cell wall,
- Indication: Aspergillosis, Candidemia, Febrile neutropenia
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Ultane
- Gen: Sevoflurane,
- Class: Anesthetic, Haloalkane,
- RoA: Inhalation,
- MOA: disrupts lipid matrix of neuronal membranes affecting gating of ion channels,
- Indication: General Anesthesia
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Seroquel
- Gen: Quetiapine Fumarate,
- Class: Antipsychotic, Dibenzothiazepine,
- RoA: Oral,
- MOA: antagonist of 5-HT1A, 2, D1,2, H1, and alpha1,2,
- Indication: Bipolar-1, MDD, Schizophrenia
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Protonix IV
- Gen: Pantoprazole Sodium,
- Class: PPI,
- RoA: Oral, IV
- MOA: inhibits acid secretion by covalently binding to the H/K ATPase pump,
- Indication: GERD, Zollinger-Ellison Syndrome, Gastric hypersecretion
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Gemzar
- Gen: Gemcitabine Hydrochloride,
- Class: Antineoplastic Agent, Antimetabolite
- RoA: IV,
- MOA: nucleoside analogue cell phase-specific for the S-phase and for the G1/S-phase, inhibits DNA synthesis,
- Indication: Breast, Ovarian, Pancreas, non-small cell lung cancers
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Erbitux
- Gen: Cetuximab,
- Class: Antineoplastic agent, (Mab) EGFR-I,
- RoA: IV,
- MOA: binds EGFR blocking phosphorylation/activation of kinases, inhibiting growth/survival of tumor cells
- Indication: Cancers (Head, neck, colorectal)
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Visipaque
- Gen: Iodixanol,
- Class: (Dye)Non-Ionic Contrast Agent
- RoA: IV,
- MOA: hypotonic, low osmolality to serum,
- Indication: Diagnostics Radiography
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Primaxin
- Gen: Imipenem/Cilastatin,
- Class: Antibiotic (Carbapenem),
- RoA: IV > IM,
- MOA: B-lactam-I/dipeptidase-I(to stop rapid metabolizing of imipenem),
- Indication: Infections (LRT, UTI, abdominal, skin, bone, endocarditis, sepsis)
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Zocor
- Gen: Simvastatin,
- Class: Antihyperlipidemic, Statin (HMG-CoA-I),
- RoA: Oral,
- MOA: HMG-CoA reductase inhibitor,
- Indication: hypercholesterolemia (CHD, diabetes, stroke, MI)
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Ms Contin
- Gen: Morphine Sulfate,
- Class: Opiate Analgesic,
- RoA: Oral,
- MOA: CNS mu opioid receptor agonist,
- Indication: Moderate to severe 24 hr pain management
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Vancocin
- Gen: Vancomycin Hydrochloride,
- Class: Antibiotic (glycopeptide),
- RoA: IV, oral,
- MOA: Blocks protein synthesis (blocks initiation, elicits premature termination, or incorporates incorrect AA),
- Indication: Methicillin-resistant staph, endocarditis
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Nexium
- Gen: Esomeprazole,
- Class: PPI,
- RoA: Oral,
- MOA: inhibits acid secretion by covalently bonding the H/K ATPase pump,
- Indication: Erosive esophagitis, GERD, NSAID-GU, H.pylori-DU, Zollinger-Ellison Syndrome
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Plavix
- Gen: Clopidogrel Hydrogen Sulfate,
- Class: Anti-coagulant, ADP-Induced AC
- RoA: Oral,
- MOA: Irreversibly binds to ADP-P2Y12 receptors on platelets to inhibit GPIIb/IIIa complex,
- Indication: MI, Stroke, Peripheral arterial disease
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Zometa
- Gen: Zoledronic Acid,
- Class: Bisphosphonate, Calcium Regulator,
- RoA: IV infusion,
- MOA: inhibits osteoclasts to lower calcium release,
- Indication: Hypercalcemia of Malignancy, Multiple Myeloma, Bone Metastases
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Gamunex
- Gen: Immune Globulin,
- Class: Immune Globulin-IgG,
- RoA: IV,
- MOA: supplies IgG antibodies, blockade of Fc receptor on macrophages
- Indication: Primary Humoral Immunodeficiency (PI), Idiopathic Thrombocytopenia Purpura (ITP), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
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Camptosar
- Gen: Irinotecan Hydrochloride,
- Class: Anti-Neoplastic Agent, Topoisomerase1-I,
- RoA: IV infusion,
- MOA: binds topoisomerase-1 DNA complex,
- Indication: colon/rectum metastic carcinoma
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Risperdal
- Gen: Risperidone,
- Class: Antipsychotic (Benzisoxazole)
- RoA: Oral, IM,
- MOA: D2 and 5HT2 antagonists,
- Indication: Schizophrenia, Bipolar,
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Zyprexa
- Gen: Olanzapine,
- Class: Antipsychotic (Thienobenzadiazepine),
- RoA: Oral, IM,
- MOA: D2, 5HT2 antagonist,
- Indication: Schizophrenia, Bipolar
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Lupron Depot
- Gen: Leuprolide Acetate,
- Class: Antineoplastic Agent, LHRH Agonist,
- RoA: IV, IM, ID, SC,
- MOA: Gonadotropin-releasing Hormone (GnRH), Luteinizing H-Releasing H,
- Indication: Anemia, Endometriosis, Prostate cancer
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Prevacid
- Gen: Lansoprazole,
- Class: PPI,
- RoA: Oral,
- MOA: inhibits acid secretion by covalently binding the H/K ATPase pump,
- Indication: DU, GERD, NSAID-GU, Zollinger-Ellison syndrome
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Zithromax
- Gen: Azithromycin,
- Class: Antibiotic (macrolide),
- RoA: Oral,
- MOA: binds 50-S ribosomal subunit (interferes with microbial protein synthesis),
- Indication: COPD, otitis media, conjunctivitis, pneumonia, gonorrhea (bacterial infections)
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Lipitor
- Gen: Atorvastatin,
- Class: Antihyperlipidemic, HMG-CoA reductase-I (statin)
- RoA: Oral,
- MOA: inhibits cholesterol synthesis, increases LDL receptors,
- Indication: Hypercholesterolemia, hyperglyceridemia, Familial type-3 hyperlipoproteinemia, CVD (prophylaxis), type 2 diabetes mellitus
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Cubicin
- Gen: Daptomycin,
- Class: Antibiotic, Lipopeptide,
- RoA: IV,
- MOA: binds cell membrane depolarizing membrane potential leading to disrupt DNA, RNA and protein synthesis,
- Indication: Bacteremia, endocarditis, staph aureus
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Suprane
- Gen: Desflurane,
- Class: Haloalkane, Anesthetic,
- RoA: Inhalation,
- MOA: increase GABA transmission, disrupts lipid matrix of neuronal membranes affecting gating of ion channels,
- Indication: General anesthesia
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Cardene I.V.
- Gen: Nicardipine,
- Class: Anti-HT, CCBlocker,
- RoA: IV, oral,
- MOA: blocks the transmembrane influx of Ca+ affecting cardiac/SM contractility,
- Indication: HT, postoperative HT, Stable angina
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Adenoscan
- Gen: Adenosine,
- Class: Adenosine R-agonist, Antiarrhythmic,
- RoA: IV,
- MOA: slows impulse formation SA node, and conduction of AV node (influence cellular Ca dynamics),
- Indication: Paroxysmal supraventricular tachycardia
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Synagis
- Gen: Palivizumab,
- Class: Immunological/antiviral, (Mab) RSV-I,
- RoA: IM,
- MOA: exhibits neutralizing and fusion-inhibitory activity,
- Indication: Respiratory syncytial virus infection (RSV)
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