Immunology

Card Set Information

Author:
noblewhit
ID:
132924
Filename:
Immunology
Updated:
2012-02-05 01:36:44
Tags:
Immunology Chapter
Folders:

Description:
Chapter 1-Overview of Immune System
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user noblewhit on FreezingBlue Flashcards. What would you like to do?


  1. Who is responsible for the 1st large scale vaccination?
    Edward Jenner
  2. What are the 4 classes of pathogens our immune system protects us against?
    1. Bacteria, 2. Viruses, 3. Fungi, 4. Parasites
  3. What are the 3 levels of protection of our immune system?
    1. Physical barriers, 2. Innate Responses, 3. Adaptive Responses
  4. Soluble Molecules vs. Cell Associated
    Cells soluble in tissue fluids, not directly associated all the time with another cell vs. cells stuck on tissues
  5. What type of cells line the mucosal layer?
    Epithelial cells
  6. What are the 4 physical immune barriers?
    • 1. pH
    • 2. Movement of material
    • 3. Secretions
    • 4. Normal Flora
  7. What are the 2 types of immunity?
    Innate and Acquired (Specific, Adaptive) Immunity
  8. What type of bond do receptor-ligand interactions have?
    Non-covalent
  9. What does recognition involve?
    Binding of one molecule to another (ligand to receptor)
  10. (T or F) During Innate Immunity responses change with subsequent exposures.
    False, they do NOT change.
  11. Germline DNA
    Genes that encode factors
  12. 4 Facts about Innate Immunity
    • 1. Responses do NOT change over time
    • 2. Recognition of pathogen
    • 3. Effector mechanisms (cells, proteins)
    • 4. Non-specific
  13. What triggers innate factors?
    Molecules that are common to many different microbes
  14. What are the 4 signs of inflammation?
    Redness, swelling, pain, heat
  15. What is inflammation caused by?
    Response to the presence of the organism
  16. Cytokines
    Allow for more effector cells to enter tissue and engulf bacteria
  17. Effector cell
    Phagocytizes bacteria via complement proteins
  18. What are the 2 characteristics of the aquired immune system?
    • 1. Responses DO change over time (10-14 days for factors to be activated)
    • 2. Highly specific
  19. What are the 2 responses of the Acquired Immune System?
    Primary & Secondary
  20. Antigen
    Antibody generator
  21. 3 Cells of Adaptive Immunity
    • 1. B-lymphocytes (Antibody-mediated Immunity) -> Plamsa cell
    • 2. Cytotoxic T Lymphocytes (Cell-mediated Immunity) : TcCell
    • 3. T-helper cells: THCell
  22. What cells are present in serum and tissues?
    Leukocytes (WBC's)
  23. Where are they derived from? What cell?
    Bone marrow; hematopoetic stem cell
  24. What is Hematopoeisis?
    "making more blood cells"; the constant need to replace RBC's and luekocytes
  25. What does the stem cell give rise to?
    new stem cell (self-renewal)
  26. What does the stem cell differentiate into?
    Progenitor cells
  27. The progenitor cells give rise to what 3 lineages?
    • 1. erythroid
    • 2. myeloid
    • 3. lymphoid
  28. What are the 3 granulocytes?
    • 1. Erythrocytes (RBC's)
    • 2. Platelets
    • 3. Megakaryocytes
  29. What types of dyes (acidic or basic) do each of the granulocytes contain? What does it bind to?
    • Neutrophils: contain Basic dyes; bind to acidic
    • Basophils: contain Acidic dyes; bind to basic
    • Eosinophils: contain Both; bind to neither
  30. What are the 3 cells of the erythoid lineage?
    • 1. Erythrocytes
    • 2. Platelets
    • 3. Megakaryocytes
  31. What are the 4 cells of the myeloid lineage?
    • 1. Granulocytes
    • 2. Monocytes/Macrophages
    • 3. Dendritic Cells
    • 4. Mast Cells
  32. What are the professional phagocytes?
    • 1. Macrophages
    • 2. Neutrophils
    • 3. Dendritic Cells
  33. Where does the myeloid lineage reside?
    Tissues
  34. What 2 cells make up the small cells of the lymphoid lineage?
    • 1. T-cells
    • 2. B-cells
  35. What cells make up the large lymphocytes of the lymphoid lineage?
    Natural killer (NK) cells
  36. What do B-Cells differentiate into?
    plasma cells
  37. What do plasma cells secrete?
    Antibodies (immunoglobulins)
  38. What is the T-Cells job?
    Cellular-mediated Immunity
  39. What are the 2 types of T-Cells?
    • 1. T-Helper Cells
    • 2. T-Cytotoxic Cells
  40. What do small lymphocytes respond specifically to?
    Antigens
  41. Where do mature T & B cells circulate?
    Blood & Lymph system
  42. What do T & B cells try to pick up?
    Antigen
  43. What immune system has memory?
    Adaptive immune System
  44. What immune system is the basis for vaccines?
    Adaptive Immune System
  45. What structure are vaccines designed to look like?
    Epitopes

What would you like to do?

Home > Flashcards > Print Preview