P.chem lec v1.1

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Author:
Anonymous
ID:
133733
Filename:
P.chem lec v1.1
Updated:
2012-02-08 13:08:40
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midterm exam
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Description:
Acronyms (anti-neoplastic drugs)
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  1. TK
    Tyrosine kinase Inhibitor
  2. TNM
    • T - tumor
    • N - lymph node involvement
    • M - metastasis
  3. CDKs
    Cyclin-dependent kinases
  4. Rb
    Retinoblastoma protein
  5. MMR
    Mismatch Repair
  6. BCNU
    Carmustine
  7. MTIC
    Monomethyl triazeno imidazole caroxamide
  8. MOPP
    • Mechlorethamine (aka HN2 or Mustargen)
    • Oncovin (vincristine)
    • Procarbazine
    • Prednisone
  9. NSCLC
    Non-small cell lung cancer
  10. CML
    Chronic myelogenous leukemia
  11. AGAT
    O-6-alkylguanine phosphoribosyl transferase
  12. 5-FU
    5-Fluorouracil
  13. TS
    Thymidylate synthase
  14. DPD
    Dihydropyrimidine dehydrogenase
  15. CDHP
    5-chloro-2,4-dihyroxypyridine
  16. 6-MPMP
    6-thioinosinate
  17. TPMT
    Thiopurine-S-methyl-transferase
  18. XO
    Xanthine oxidase
  19. GARFT
    Glycinamide ribonucleotide formyl transferase
  20. DHFR
    Dihydrofolate reductase
  21. IRP-1
    Iron regulatory protein-1
  22. MLL
    Mixed lineage leukemia
  23. ALL
    Acute Lymphoblastic Leukemia
  24. MAPs
    Microtubule-associated proteins
  25. MDR
    Multidrug resistance
  26. Pgp
    Permeability glycoprotein
  27. MRP1
    Multidrug resistance protein
  28. ABVD
    • Adriamycin
    • Bleomycin
    • Vinblastine
    • Dacarbazine
  29. SH2
    Src homology 2 domain
  30. MAPK
    Mitogen activated protein kinase
  31. EGF
    Epidermal growth factor
  32. PDGF
    Platelet-derived growth factor
  33. NGF
    Nerve growth factor
  34. VEGF
    Vascular Endothelial growth factor
  35. SCF
    Stem cell factor
  36. GFL
    Glial cell line-derived neurotropic factor
  37. RCC
    Renal Cell Carcinoma
  38. GIST
    GI stomal tumors

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