DA Other Anti-bacterials.txt

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Author:
HUSOP2014
ID:
133943
Filename:
DA Other Anti-bacterials.txt
Updated:
2012-02-10 11:35:44
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HUSOP DA EXAM2 Misc Anti bacterial agents
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Question on mis antibacterial agents
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  1. T/F: Colistin (Polymixin E) is amphipathic but Polymixin B is not.
    False: all polymixins are amphipathic
  2. The MOA of polymixin B and Colistin (Polymixin E) is:
    • Interacts with phospholipids,
    • Disrupts the cell membrane,
    • Forming large openings that leak out cellular components.
  3. Which of the following is not true of Polymixin B/E?
    A) It is bacteriocidal causing the phospholipid membrane to leak.
    B) It has the same specificity for bacteria as it does for eukaryote cells.
    C) used to treat resistant gram negative bacteria.
    D) contains a large circular ring and is amphipathic.
    B is not true, specific to bacteria over eukaryote
  4. If Colistin is poorly absorbed orally, why is it available in oral form or what would it be used for orally?
    • Prophylactically before GI surgery,
    • to clear the bacteria from the GI tract.
  5. What is the AE for systemic use of Polymixin B or Colistin (Polyixin E)? Why does Colistin have a Parenteral use or what is it use for?
    • It is extremely nephrotoxic,
    • For last-line therapy
  6. What are the administration forms of Polymixin B/E?
    • Topically,
    • Opthalmic,
    • Otic,
    • Limited oral or parenteral
  7. T/F: The bacteriocidal effect of Vancomycin stems from the binding to the LCP blocking the binding of the peptidoglycan chain.
    True: Binds with high affinity to D-alanyl-D-alanine of LCP-NAM-NAG precursor.
  8. Which of the following is not true of the effects of Vancomycin on bacteria?
    A)only effective against Gram positive bacteria,
    B) used for methicillin-resistant Staphylococci,
    C) moderately effective against mycobacteria,
    D) can treat C. diff orally
    C is not true, It has no effect on Gram Positive or Mycobacteria
  9. Which one of the following is a AE of Vancomycin?
    A) Ototoxicity,
    B) Nephrotoxicity,
    C) Hypersensitivity reactions,
    D) "Red-man" syndrome,
    E) All of the above
    E is correct
  10. Which of the following is not true of Vancomycin?
    A) has no bacterial resistance
    B) Not well-absorbed orally,
    C) used orally form C. diff,
    D) renally excreted,
    E) IV administration,
    A) is False, there is resistance from enterococci, staphylococci (methicillin resistant strains)
    (this multiple choice question has been scrambled)
  11. T/F: The MOA of Vancomycin is similar to Teicoplanin.
    TRUE
  12. The MOA of Teicoplanin contains which of the following:
    A) Binds the LCP-NAM-NAG precursor,
    B) Blocks the connection to the peptidoglycan chain,
    C) Mostly Bacteriocidal,
    D) All the above,
    E) None of the above
    D is correct
  13. Which of the following is not an AE of Teicoplanin?
    A) Hypersensitivity reactions,
    B) Ototoxicity,
    C) Chills and Fever,
    D) All of the above,
    E) none of the above
    D is correct
  14. Which is the MOA of Daptomycin?
    A) Binds the LCP-NAM-NAG precursor to block connection in peptidoglycan chain,
    B) Disrupts the cell membrane creating large leaky openings
    C) inhibits peptidoglycan subunits across the cell membrane, D) Binds to bacterial membrane leading to depolarization and loss of membrane potential.
    D is correct- depolarization-loss of membrane potential
  15. Which of the following is not true about Daptomycin:
    A) Effective against Gram Positive Bacteria,
    B) Effective against Vancomycin-resistant Gram Positive bacteria,
    C) Toxic to muscles when injected intramuscularly,
    D) All of the above,
    E) None of the above
    E is correct
  16. Which of the following is the MOA of Bacitracin?
    A) Binds the LCP-NAM-NAG precursor to block connection in peptidoglycan chain,
    B) Disrupts the cell membrane creating large leaky openings
    C) inhibits peptidoglycan subunits across the cell membrane, D) Binds to bacterial membrane leading to depolarization and loss of membrane potential.
    C is correct
  17. T/F: Bacitracin is effective against many Gram Positive bacteria.
    True
  18. T/F: Bacitracin has little adverse effects when given IV, but is nephrotoxic if taken orally.
    • False:
    • Little with topical administration,
    • Parenteral results in Nephrotoxicity
  19. Neosporin contains which of the following?
    A) Bacitracin, Daptomycin, and Polymixin B,
    B) Vancomycin, Bacitracin, and Polymixin E,
    C) Polymixin B, Neomycin, and Teicoplanin,
    D) All of the above,
    E) None of the above
    E is correct: Neomycin, Polymixin B, and Bacitracin

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