Pharm 430

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Author:
jaguavai
ID:
134060
Filename:
Pharm 430
Updated:
2012-02-09 17:29:13
Tags:
Roseman 2014 Pharm 430
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Description:
Zheng and Kauffman
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  1. Solvolysis/hydrolysis drugs (5)
    • Aspirin
    • Tetracaine
    • Procaine
    • Penicillin
    • Cephalosporin
  2. Hydrolysis strategies (5)
    • Desicant packets (tablets)
    • Replace solvent (liquids)
    • Micelles (liquids)
    • Buffer pH (liquid)
    • Store as a dry powder (liquid)
  3. Oxidation-Reduction drugs (4)
    • Vitamin C
    • Epinephrine
    • Morphine
    • Phenothiazines
  4. Oxidation-Reduction strategies (5)
    • Purge O2 from container
    • Buffer pH
    • Store at lower temp
    • Chelating agents(EDTA, citric acit, tartaric acid)
    • Antioxidants(sulfites, ascorbic acid, thioglycolic acid, vitamin E, butylated hydroxytoluene)
  5. Chelating agents (3)
    EDTA, citric acit, tartaric acid
  6. Antioxidants (6)
    sulfites, ascorbic acid, thioglycolic acid (water soluble)

    vitamin E, butylated hydroxytoluene (lipid soluble)
  7. Photolysis drugs (2) and strategies (2)
    • Riboflavin
    • Phenothiazines
    • Amber bottles
    • Coat tablets with UV absorbing film
  8. Racemization drugs (2) and strategies (4)
    • Epinephrine
    • Tetracycline (epimerization)
    • Store at lower temps
    • Change the solvent
    • Remove catalysts
    • Protect from light
  9. Isomerization drugs (2) and strategies (4)
    • Vitamin A
    • Betamethasone 17-valerate
    • Store at lower temps
    • Change the solvent
    • Remove catalysts
    • Protect from light
  10. Adsorption drugs (3) strategies (2)
    • Nitroglycerin
    • Insulin
    • Diazepam
    • Use glass containers
    • Change to tablets
  11. Lapinski's rule of 5 for poor oral absorption (4)
    • More than 5 hydrogen bond donors
    • More than 10 hydrogen bond acceptors
    • Molecular weight > 500
    • Log P > 5
  12. Cosolvents (4)
    • Ethanol
    • Propylene Glycol
    • Polyethylene Glycol
    • Glycerin
  13. Preservatives (8)
    • 85% W/V sugar solutions
    • Alcohol
    • Benzyl alcohol
    • Phenols
    • Benzoic acid
    • Sodium benzoate
    • Sorbic acid
    • Parabens
    • Benzalkonium chloride
  14. Sweetners (5)
    • Sucrose
    • Aspartame
    • saccharin
    • sorbitol
    • corn syrup
  15. Flavorants (4)
    • Methylsalicylate
    • Peppermint oil
    • Wild cherry
    • Vanilla
  16. Colorants (3)
    • Ferric oxide
    • Titanium oxide
    • Carbon black
  17. pH Buffers (3)
    • Citric acid/sodium citrate
    • Acetic acid/sodium acetate
    • phosphate buffers
  18. Wetting agents (2)
    • Alcohol
    • Glycerin
  19. Viscosity inducing agents (8)
    • Acacia gum
    • Xanthan gum
    • pectin
    • locust bean gum
    • methyulcellulose
    • carboxymethylcellulose
    • hydroxypropyl cellulose
    • carbomers
  20. Anionic surfactants (2)
    • Soap
    • sulfated compounds
  21. Cationic surfactants (2)
    • cetyl trimethyl ammonium bromide,
    • benzalkonium chloride
  22. Nonionic surfactants (2)
    • Spans
    • Tweens
  23. Amphoteric surfactant (1)
    Lecithin

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