Quiz 3 (Ch. 4)
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Quiz 3 (Ch. 4)
Name an alkylating agent.
What is the alkylating agent MOA?
forms strong covalent bonds with DNA inhibiting replication and causing bond breaks and cell death
Common SE for Cyclophosphamide?
Adverse/Rare SE Cyclophosphamide?
renal tubular necrosis
Which antineoplastic should be taken early in the day if taken orally?
Which antineoplastic requires patient to drink 3-4 Liters of water after an IV injection?
Which antineoplastic needs mesna uroprotection to prevent hemorrhagic cystitis?
What other drugs does cyclophosphamide have an effect on?
Name an anthracycline.
Which antineoplastic is known for the risk of cardiotoxicity?
Which antineoplastic is a vesicant and can cause severe skin necrosis if extravasation occurs?
Which antineoplastic is only an IV?
What is the anthracycline MOA?
inhibits DNA and RNA synthesis by intercalation of DNA base pairs and inhibition of DNA repair by topoisomerase
T/F: anthracyclines can be used to treat non-malignant diseases.
What are the most notable side effects for alkylating agents?
bone marrow suppression
T/F: alkylating agents can be used to treat both malignant and non-malignant diseases.
What are the adverse/rare SE of Doxorubicin?
acute and delayed cardiotoxicity
What other drugs can Doxorubicin affect?
What drugs could have an affect on Doxorubicin?
trastuzumab (could increase cardiotox)
No live virus vaccines should be given during therapy with which drugs?
Which drug could darken the urine for 24-48 hours?
You should watch for fever, malaise, sore mouth or throat, pain or swelling near injection site when taking this drug?
Patients should have ejection fraction measured before starting therapy with this drug?
Which antineoplastics are similar in structure to naturally occurring compounds?
What is the MOA of antimetabolites?
kill tumor cells by inhibiting DNA synthesis by a specific mechanism or they incorporate themselves into DNA, causing apoptosis
Rare/Adverse SE of Capecitabine?
What drug can enhance the toxic effect of Capecitabine?
What drug can Capecitabine have an adverse effect on ?
Which drug should the sunlight be avoided and wear sunscreen with?
T/F: Capecitabine needs to be taken with food.
T/F: Capecitabine can be taken within two hours of an antacid.
Which drug can cause a painful rash on the hands and feet?
Rare/adverse SE of cytarabine?
tumor lysis syndrome
ocular toxicity (eye)
T/F: cytarabine does not have any major drug interactions.
Changes in mental status may occur during therapy with which drug?
What drug requires aggressive water intake and antiemetic therapy?
Which drug requires steroid eye drops to prevent ocular toxicity?
Which drug comes in a topical cream or solution dosage form?
Most common rare/adverse SE of 5-fluorouracil?
What other drugs can 5-fluorouracil have an affect on?
Which drug should you not take alcohol with?
Should you avoid sunlight if you are taking 5-fluorouracil?
Which drug can cause severe diarrhea and mucositis?
If you have a genetic deficiency of dihydropyrimidine dehydrogenase, which drug might cause you to have increased systemic toxicities?
What drug class is capecitabine?
What drug class is cytarabine?
What drug class is 5-fluorouracil?
What drug class is gemcitabine?
What drug class is mercaptopurine?
What drug class is methotrexate?
What drug class is doxorubicin?
What drug class is cyclophosphamide?
What drug class is carboplatin?
What drug class is cisplatin?
What drug class is Imatinib?
What drug class is Rituximab?
What drug class is Trastuzumab?
What drug class is Docetaxel?
What drug class is paclitaxel?
What are rare/adverse SE of gemcitabine?
What other drugs can gemcitabine effect?
Which drug can cause severe flu-like symptoms to occur?
Need to watch for fever, bleeding and bruising if you are taking ___?
Which drug can increase the toxicity of radiation if given concurrently with radiation?
Thrombocytopenia is common with use of this antimetabolite?
Rare/adverse SE of mercaptopurine?
Which drug can increase mercaptopurine levels?
What other drug can mercaptopurine have an effect on?
Which antimetabolite should be taken on an empty stomach and is used to treat Crohn's?
Which drug has been associated with writing prescriptions with sixfold overdosage?
(do not write 6-MP!!)
Which antimetabolite should be taken in the evening to lower the risk of relapse?
Which drug can be tested for risk of toxicity using TPMT genotyping?
Which drug can be used for an ectopic pregnancy?
What are the rare/adverse SE for methotrexate?
encephalopathy (with IT administration)
What other drug can methotrexate have an adverse effect on?
What other drugs could affect methotrexate (a lot)?
T/F: prolonged exposure to sunlight should be avoided when taking methotrexate.
Which antimetabolite should not be administered with radiation therapy?
When giving an IT injection of this drug, a preservative-free solution needs to be used?
Leukovorin must be given when using high doses of this drug to prevent severe life-threatening myelosuppressionand mucositis?
Avoid this drug in patients with third spacing like ascites or effusions?
Which agents are cell cycle nonspecific agents that are directly toxic to DNA by causing strand breaks to form?
What is the MOA of the platinum compounds?
form strong covalent bonds with DNA inhibiting replication and causing cell death
What are adverse/rare SE of carboplatin?
Which drug class should you avoid taking with carboplatin (or cisplatin too)?
aminoglycosides because will increase risk of ototoxicity (gentamicin)
Which drug should you absolutely not take if you are pregnant or breastfeeding?
This platinum compound can cause severe N/V?
This platinum compound should be taken with plenty of fluids after chemo therapy?
Hypersensitivity risk increases after 6+ treatments with this drug?
What is the most common adverse SE of cisplatin?
For which drug should you verify any dose written for over 100 mg/m
Ototoxicity is more common in children than adults with this drug?
This platinum compound is highly emetogenic?
IV hydration should be given before and after _____ therapy?
While on this drug, potassium and magnesium levels especially should be monitored?
Renal function should be assessed before giving this drug?
What other drugs can affect cisplatin?
What other drugs can cisplatin have effects on?
Mannitol or furosemide can be given with this drug to reduce nephrotoxicity?
This class kills tumors by targeting abnormal genetic signaling proteins specific to the cancer and many are used in combo with other cytotoxic drugs?
What is the MOA of Imatinib?
inhibits tyrosine kinase needed for cell proliferation and targets the Philadelphia fusion gene
What is the MOA of Rituximab and Trastuzumab?
they are monoclonal antibodies that target CD-20 antigen on B-cells and the HER2/neu oncogene, respectively
What are the adverse SE of Imatinib?
severe bullous dermatologic reactions
What drugs can affect Imatinib?
What other drugs can Imatinib effect?
Which drug has the common side effect of fluid retention or edema?
What drug has a common side effect of infusion reaction?
Which drug is recommended to be pretreated with benadryl and APAP?
Which drug can reactivate serious infections like Hepatitis B?
Patient should report shortness of breath, chest tightness, fever or chills during treatment with this drug?
What other drug can Rituximab have an effect on?
What are the rare/adverse SE of Rituximab?
severe or fatal mucocutaneous reactions
toxic epidermal necrolysis
bowel obstruction and perforation
progressive multifocal leukoencephalophathy
Which drug is used to treat early stage and metastatic breast cancer?
What are rare/adverse SE of trastuzumab?
Which two drugs are known well for their cardiotoxic effects?
T/F: patient should have ejection fraction measured before starting therapy with trastuzumab.
Patients treated with trastuzumab should report immediately what symptoms?
shortness of breath
What other drugs can trastuzumab effect?
Which drug class is known for its bone marrow suppression and peripheral neuropathies?
What is the MOA of taxanes?
stabilize the microtubule bundles by promoting assembly and preventing depolymerization, thereby inhibiting cell replication
What are the rare SE for Docetaxel?
You should report any fever or infection to Dr. with what drug?
Which drug must you premedicate with a corticosteroid to reduce fluid retention?
T/F: taxanes should be given before platinums when given together to limit toxicity.
What are the rare SE for paclitaxel?
You can experience bradycardia if you are taking which drug?
Infection and peripheral neuropathies can be seen with prolonged use of this drug?
____ is a radiosensitizer and will increase effect and toxicity of radiation therapy?
Monitor blood pressure regularly while infusing this drug?
Severe bone marrow suppression is possible when taking this drug?
Premedicate with corticosteroid, benadryl, H2 blocker (histamine) to prevent hypersensitivity with which drug?
Which drug class will cause tissue necrosis if extavasation occurs?