Name the 4 main mechanisms of reistance for Macrolides.
1. Drug efflux form the cell
2. Addition of methly group to the ribosome (by a methylase) causing a reduction in the affintiy of the ribosome to the macrolide.
3. Hydrolysis of macrolide by an esterase
4. Chromosomal mutations that alter a 50s ribsomal protein