DA Exam II Anti-malarial Agents

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Anonymous
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DA Exam II Anti-malarial Agents
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2012-02-10 15:47:59
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DA Exam II Anti-malarial Agents
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  1. Malaria afflicts _________ individuals world-wide with _______ deaths per year.
    About 500 million; 2 million
  2. Malaria is caused by which parasite and what is it generally carried by?
    Plasmodium falciparum; Anopheline mosquito
  3. What populations are particularly sensitive to malaria?
    Children < 5 yoa, pregnant women and non-immune individuals.
  4. What interrupted the transimission of malaria in the USA in the 1950s?
    DDT and other pesticide use controlling mosquitoes
  5. What causes all cases of malaria within the USA today?
    Exposure outside the country.
  6. Name the three cities/states with the highest number of reported cases of malaria in 2007.
    NYC, California and Texas (where most people from outside the country visit)
  7. When are the symptoms of malaria most pronounced?
    During disruption of the erythrocytes.
  8. What are the symptoms of malaria?
    Headache, fever, muscular fatigue and pain, back pain, chills, sweating, dry cough, spleen enlargement, and n/v.
  9. Plasmodium infection transmission is by blood transfer, primarily by the mosquito bite of the _______________.
    female Anopheline
  10. What in the Anopheline salivary glands enters the body and homes to the liver?
    Sporozoites
  11. Within the liver, sporozoites transform into tissue ______ and ________.
    schizonts; multiply
  12. How long does the liver stage last? What symptoms are usually present?
    5 to 15 days. Generally asymptomatic depending on which of 4 Plasmodium species involved.
  13. During which phase do tissue schizonts rupture, each releasing thousands of merozoites that enter the RBCs?
    Erythrocytic Phase
  14. Merozoites asexually develop into ______ and then mature ______.
    trophozoites; schizonts
  15. During the erythrocytic phase, when RBCs rupture, what are released?
    Merozoites, which can infect other erythrocytes
  16. What type of attaches can result from rupture of the erythrocytes?
    Febrile
  17. Put the following in order based on which comes first: tissue schizonts, trophozoites, merozoites, mature schizonts, sporozoites
    Sporozoites transform into tissue schizonts in the liver, tissue schizonts rupture and release merozoites, merozoites asexually develop into trophozoites then mature schizonts.

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