PD DRUGS

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Author:
mminnick
ID:
134526
Filename:
PD DRUGS
Updated:
2012-02-12 19:49:12
Tags:
regis university
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Description:
IP7
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  1. Carbidopa/Levadopa
    • dopamine precursors
    • when COMT is blocked, O-methylation is major pathway
    • do not take with MAO-A inhibitors
    • carbidopa decreases N by delaying conversion of DOPA until after it reaches brian.
    • IR 2000mg daily; CR 1600 daily
  2. Bromocriptine
    • dopamine agonist
    • 100mg daily
  3. Pramipexole
    • dopamine agonist
    • renal dosing reqd
    • IR & ER 4.5mg daily
  4. Ropinorole
    • dopamine agonist
    • metabolized by 1A2
    • IR 9mg daily; XL 24mg daily
    • 1A2
  5. Apomorphine
    • dopamine agonist
    • SQ injectable to treat "off" episodes
    • renal adjustment reqd
    • can cause SEVERE emesis
    • SQ dosing pen
  6. Rasagiline
    • MAO irreversible inhibitor
    • metabolized by 1A2
    • meperidine and dextroamphetamine are contraindicated
    • may cause orthostatic hyportension
  7. Selegiline
    • MAO irreversible inhibitor
    • inhibits DA reuptake in the cleft
    • metabolized by 450
    • lead to methamphetamine and amphetamine metabolites
    • (reduced by OTD)
    • meperidine, dextroamphetamine are contraindicated
    • may cause orthostatic hypotension
    • PO 10mg daily; ODT 2.5mg daily
  8. Entacapone
    • COMT inhibitor
    • bc of short half life (2 hrs), must be taken with carbidopa/Ldopa
    • red urine
    • 1600mg daily w/ levadopa
  9. Tolcapone
    • COMT inhibitor
    • goes into CNS
    • must monitor liver enzymes
    • red urine, increase in LFTs
  10. Benztropine
    • anticholinergic
    • eliminated via unchanged drug
    • 6mg daily; PO or 1mg/ml solution
  11. Trihexyphenidyl
    • antichlinergic
    • 15mg daily (2mg/5mL elixer)
  12. Amantadine
    • eliminated via glomular filtration
    • can reduce dyskinesais by 70%
    • 400mg daily divied doses
    • syrup

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