What is an example of a drug that creates an epoxide that can be isolated from the urine and has even been found in drinking water in CA? In this case, the epoxide metabolite is the ACTIVE drug. Oxidation of C=C olefin.
What is the indication of carbamazepine (tegretol)?
partial and clonic-tonic seizures (anticonvulsant)
What is another drug that undergoes olefinic oxidation via an intermediate epoxide?
What is the indication of secobarbitol?
short duration anesthetic
What are two drugs that undergo benzylic oxidations?
What is the indication of metoprolol?
What is the indication of tolmetin?
What are three drugs that undergo allylic oxidation?
What is the indication of Pentazocine (Talwin)
narcotic used for pain
used for pre- or post op anesthesia
Quinaglute Dura Tabs
What is the indication of quinidine?
Which quinidine brand causes GI upset?
Quinidex Extendtabs (sulfate salt)
Which form of quinidine cause much less GI upset?
the sugar salts (compared to the sulfate salt)
What is the indication of glutethimide?
insomnia (use for 3-7 days)
What are two drugs that are oxidated at an alpha carbon next to carbonyl or an imine?
What is Diastat?
rectal diazepam gel
Why would you use Diastat?
if you have N/V and you can't keep your oral anticonvulsant down
also for anxiety, skeletal muscle relaxant
What drug does the metabolite Oxazepam stem from?
What is Oxazepam used for?
for detoxing an alcoholic
What are two drugs that undergo aliphatic oxidation?
What is the indication for Chlorpropamide?
oral anti-diabetic sulfonylurea
What are two drugs that undergo oxidation at alicyclic carbons?
Minoxidil (Loniten, Rogaine)
What is the indication of Acetohexamide (Dymelor)?
oral antidiabetic sulfonylurea
What is minoxidil indicated for (two things)?
severe unresponsive hypertension (loniten)
male pattern baldness (rogaine)
What are 4 examples of tertiary aliphatic and alicyclic amine oxidations?
Tamoxifen Citrate (Nolvadex)
What is the indication of Chlorpromazine (Thorazine) and Phenothiazine?
tab, cap, supp, syrup, injection
What drug cause the thorazine shuffle?
chlorpromazine (thorazine) or phenothiazine
it is neurotoxic
What is the the #1 drug for treating breast cancer?
tamoxifen citrate (nolvadex)
What are 4 examples of oxidations of primary and secondary amines?
Phentermine (Ionamin, Adipex-P, Zantryl, Fastin)
What is propranolol indicated for?
beta blocker (non-selective)
test anxiety/stage fright
What is the indication of Methylphenidate?
What is phentermine indicated for?
used to study hardcore
What is (dl)-Amphetamine sulfate indicated for?
What drug makes metabolites like an imine, an oxime and phenylacetone, which can be found in the urine of meth users?
What are two drugs that undergo oxidation of nitrogen heterocycles?