CV Module_Diuretics

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Author:
fallcloud13
ID:
135557
Filename:
CV Module_Diuretics
Updated:
2012-02-16 16:42:13
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CV Diuretics
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CV Module_Diuretics
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  1. Mannitol
    • Osmotic Diuretic
    • Osmitrol-IV
    • Used for head injury (reduce cerebral edema)
  2. Glycerin
    • Osmotic Diuretic
    • Osmoglyn-PO
  3. Isosorbide
    • Osmotic Diuretic
    • Ismotic-PO
  4. Acetazolamide
    • CAIs
    • Diamox
    • Open-angle glaucoma, Acute mountain sickness
    • Causes Metabolic Acidosis, renal stone formation, ammonia circulation (hepatic)
  5. Methazolamide
    • CAIs
    • Glauctabs
    • Open-angle glaucoma, Acute mountain Sickness
    • Causes Metabolic Acidosis, renal stone formation, ammonia circulation (hepatic)
  6. Furosemide
    • Loop
    • Lasix-PO, IV
    • High protein bound, 50% kidney glucoronidation
    • Short t1/2(1-3hr), hypokalemic alkalosis,Ototoxicity, hyponatremia, hyperuricemia-gout, hypomagnesemia
  7. Bumetanide
    • Loop
    • Bumex-PO, IV
    • High PO absorption, Hepatically metabolized
    • Short t1/2(1-3hr), hypokalemic alkalosis,Ototoxicity, hyponatremia, hyperuricemia-gout, hypomagnesemia
  8. Torsemide
    • Loop
    • Torsemide- PO, IV
    • High PO absorption, Hepatically metabolized
    • Short t1/2(1-3hr), hypokalemic alkalosis,Ototoxicity, hyponatremia, hyperuricemia-gout, hypomagnesemia
  9. Ethacrynic Acid
    • Loop
    • Short t1/2(1-3hr)
  10. Chlorothiazide, Hydrochlorothiazide, Methyclothiazide, Polythiazide
    • Diuril, Hydrodiuril, Enduron, Renese
    • Na/Cl Symporter of DCT
    • Hypokalemia, Hypovolemia, Hyponatremia,Hypercalcemia, Hypomagnesemia, decreased glucose tolerance, increase cholesterol, TG level, Impotence
    • Usage: Edema (ineffective at GFR<30), Hypertension
  11. Chlorthalidone
    thiazide-like
  12. Indapamide
    thiazide-like
  13. Metalozone
    thiazide-like
  14. Amiloride
    • K-sparing Diuretics
    • ENaC of principal cells of late DCT and collecting duct
    • Usage: HTN, Edema, Liddle's Syndrome
  15. Triamterene
    • K-sparing Diuretics
    • ENaC of principal cells of late DCT and collecting duct
    • Usage: HTN, Edema, Liddle's Syndrome
  16. Spironolactone
    • MR antagonist
    • Basolateral side of renal epithelial cells
    • Usage: Edema, HTN, Hepatic cirrhosis, HF
  17. Eplerenone
    • MR antagonist
    • Basolateral side of renal epithelial cells
    • Usage: Edema, HTN, Hepatic cirrhosis, HF

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