Uses: Deep vein thrombosis, atrial fibrillation, pulmonary embolism, heart valve replacement, rhumatic or ischemic heart Dz.
ADE: Bleeding, GI upset, necrosis, eye heme
Admin: PO wiht long T1/2 b/c of scrubbing protein
- D:D: NSAIDs, asprin, plavix, Abx, heparin, thrombolytic agents increase risk of bleeding.
- -reduced effects by rifampin which induces cyto P450
- -effects reversed by vitamin K