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Uses: Deep vein thrombosis, atrial fibrillation, pulmonary embolism, heart valve replacement, rhumatic or ischemic heart Dz.
ADE: Bleeding, GI upset, necrosis, eye heme
Admin: PO wiht long T1/2 b/c of scrubbing protein
- D:D: NSAIDs, asprin, plavix, Abx, heparin, thrombolytic agents increase risk of bleeding.
- -reduced effects by rifampin which induces cyto P450
- -effects reversed by vitamin K
Uses: dec. risk for AMI, stroke & TIAs
ADE: GI ulcer, bleeding, blurred vision
Admin: Liver metabolism
D:D: inc. bleeding risk, inc. GI effects
Uses: dec. thrombotic events after a recent AMI or stroke
ADE: GI ulcer, bleeding, Neutropenia, rare thrombotic TCP purpura with Triclopidine, Conjunctivitis, cataracts.
Admin: PO and is metabolized into active drug
D:D: Inc. risk for bleeding when taken with other anti-thrombotics