Neuropath - Dementia and Degeneration

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Neuropath - Dementia and Degeneration
2012-08-02 05:35:20

Imaging, Gross, and Histopathological Images of the Dementias
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  1. Diffuse cortical atrophy as commonly seen in Alzheimer's Disease
  2. Alzheimer's Disease
  3. Granulovacuolar bodies as seen in Alzheimer's Disease
  4. Hirano Body as seen in Alzheimer's Disease
    • Silver stain demonstrating plaques and tangles as seen in Alzheimer's Disease
    • Tangles have a "flame-shaped" appearance
    • Plaques look like "burned-out camp fires"
  5. GranulovacularDegeneration small cytoplasmic vacuoles with a single granule
  6. Hirano Bodies as seen in AD
    • Alzeheimer's Disease
    • Neurofibrillary Tangle
  7. "spikey ball" pathology seen in Kuru
  8. Spngiform changes typical for CJD
  9. Pulvinar hyperintensity commonly seen in CJD
  10. Putamenal hyperintensity seen in CJD
  11. Lewy Bodies typical of Dementia with Lewy Bodies
  12. Knife-edged pattern of gyral atrophy typical for Pick's Disease
  13. SIlver stain showing Pick Bodies and Tangles
  14. Neuromelanin accumulations as seen in progressive supranuclear palsy
  15. Loss of dopaminergic neurons in the substantia nigra as seen in Parkinson's Disease
  16. Atrophy of the caudate as seen in Huntington Disease
  17. Gross spongiosis as can be seen in CJD
  18. White matter changes sparing the U-fibers as can be seen in leukodystrophies like Karabbe, Metachromatic, and Adrenoleukodystrophy.

    NOTE: Canavans and Alexanders affect the U-fibers.
  19. Cresyl Violet stain showing brown discoloration of Myelin seen in MLD
  20. Spongiform changes seen in Canavan’s Disease which are similar to CJD
  21. Rosenthal Fibers which are eosinophilic astroytic inclusions also seen in PikocyticAstrocytomas