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What chemotherapeutic drug acts as a purine analog and is resistant to adenosine deaminase?
Purine analogs used as chemo?
- Purine as in 6-Mercaptopurine
DOC for Hairy cell leukemia?
Imperforate anus often accompanies what other developmental defects?
Urinary tract defects
All dehydrogenase require what vitamins?
vitamins b1, b2, b3, b4, b5
What histological change takes place after Acute Tubular necrosis?
What disease produces type 1 RPGN?
Type 2 RPGN?
Type 3 RPGN?
- Type 1 RPGN---Good Pasture--Antibody mediated
- Type 2 RPGN--SLE, PSGN--immune complex
- Type 3-- pauci-immune--Microscopic Polyangitis--p-anca or Wegeners
Most common cause of saddle nose deformity?
Where is caseous, liquifactive, coagulation, fat necrosis taking place?
- coagulation--everywhere else
In polycythemia, what helps distinguish between relative and absolute erythrocytosis?
RBC mass which is normal in relative polycythemia and increased in absolute
What hypoxic level of oxygen drives absolute appropriate polycythemia?
SO2 <92% or P02 <70 mm Hg
Antidote for cisplatin toxicity?
S/E of Niacin therapy?
- Decreased BP
Side effect of Poiglitazones?
weight gain and edema due to increased insulin activity because insulin stimulates anabolic reactions i.e Fat synthesis
Gross hematuria, proteinuria, kidney tissue fragments in urine all suggest what kidney pathology?
Renal Papillary necrosis
2 conditions giving cafe au-lait spots?
- Mccune Albright syndrome--precocious puberty
Intestinal atresia occur due to what?
The hypercapneic drive is detected by which receptors? Central or peripheral?
Hypoxic drive i.e low O2 is detected by what ?
- carotid body
Regurgitation murmurs have what type of sound?
What is the first gene mutated in sporadic and in Familial Polyposis syndrome?
What antibiotic regimen is used to treat Tb?
What kind of insulin is given to treat DKA?
2 Intermediate acting insulin?