What is the relevance of this to clinical use of these agents?
doesn't want to dissolve into blood, so builds up to a high level in alveoli first, then enters blood rapidly. also, tends to stay in blood because doesn't enter other tissues easily - except for brain, which has large blood supply, high lipid content.
End result: enters blood rapidly, enters brain rapidly, anesthestizes patient rapidly. also the process reverses rapidly when the administration of the agent stops so recovery occurs rapidly.