Gout

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Author:
capnhue
ID:
135948
Filename:
Gout
Updated:
2012-02-29 21:57:13
Tags:
Regis University
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Description:
Gout
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  1. Pathology of Gout
    • asymptomatic hyperuricemia
    • acute gouty arthritis
    • intercritical gout
    • chronic tophaceous gout
  2. Allopurinol Drug-drug interactions
    • mercaptopurine
    • azathioprine
    • cyclophosphamide
    • captipril
    • enalapril
    • Contraindicated: didanosine
  3. Febuxostat Drug-drug interactions (contraindicated)
    • mercaptopurine
    • azathioprine
    • theophylline
  4. drug-drug interactions w/Allopurinol
    • mercaptopurine
    • azathioprine
    • cyclophosphamide
    • captopril
    • enalapril
    • *didanosine - Contraindicated
  5. drug-drug interaction w/ Febuxostat
    • mercaptopurine
    • azathioprine
    • theiphylline
  6. Acute Gouty Arthritis treatment
    • first line: NSAIDs
    • second line: colchicine
    • third line: corticosteroids
  7. Interval Gout Treatment (prophalaxis)
    • xanthine oxidase inhibitors: allopurinol1st line, febuxostat2nd line (for overproducers)
    • uricosurics: probenecid (for underexcretioners)
  8. Contraindications of Uricosurics (probenecid)
    • CrCl: < 50
    • history of renal stones
    • overproducers
    • *caution w/aspirin: aspirin may interfere w/ MOA of probenecid
  9. Allopurinol adverse effects
    • CrCl: < 80 dose adjustment needed
    • allopurinol hypersensitivity syndrome: severe rash, hepatitis, interstitial nephritis, eosinophilia
  10. Probenecid (uricosurics) adverse reactions
    • GI irritation
    • rash
    • hypersensitivity
    • precipitation of kidney stones
  11. Treatment for chronic gout
    • allopurinol
    • febuxostat
    • probenecid
    • pegloticase
  12. neprolithiasis (kidney stones) treatment
    • hydration maintain ruine volume 2-3liters/day
    • potassium bicarb
    • potassium citrate
    • acetazolamide
    • *allopurinol for recurrent uric acid nephrolithiasis

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