MedChem Quiz IIII

Card Set Information

Author:
ba
ID:
136012
Filename:
MedChem Quiz IIII
Updated:
2012-02-18 16:06:00
Tags:
MedCHem Quiz IIII
Folders:

Description:
MedChem Quiz IIII Drugs
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user ba on FreezingBlue Flashcards. What would you like to do?


  1. Alerdronate
    • Fosamax
    • Redflag drug
    • Osteoporosis
    • Biophosphate derivative
    • BIndds to bone hydroxapatite and inhibits osteoclast-mediated bone resorption
  2. Tagamet
    • Cimetidine
    • Red Flag Drug
    • GERD
    • H2 antagonist
    • Substrate for Organic Cation transporter
  3. Propulsid
    • Cisapride
    • GERD
    • Red flag drug
    • Compassionate use only program
    • Gastronintestinal Agent Prokinetic
    • Enhances the release of acetylcholine at the myenteric plexus
  4. Neoral
    • Cyclosporine
    • Immunosuppressant
    • Calcineurin inhibitor
    • Inhibit of the production and release of interleukin II
    • Used in zenograft transplant
    • Inhibitor for P-Glycoprotein

    Red Flag Drug


    • A CYP3A4 substrate, increase lovastatin levels, myopathy rhabdomyolysis
    • No interaction with pravastatin and fluvastatin
  5. Lanoxin
    • Digoxin
    • CHF Congestive Heart Failure
    • Antiarrythmic agent, Cardiac Glycoside
    • Inhibitition of the sodium/potassium ATPase pump leading to increaed contractility
    • P-glycoprotein substrate
    • Red Flag Drug
  6. Sporanox
    • Itraconzole
    • Antifungal agent
    • Interferes with cytochrome P450 activity inghibiting cell membrane formation
  7. Eskalith
    • Lithium
    • Manic depressive illness
    • Antimanic Agent
    • Alterscation transport across cell membrane in nerve and muscle cells influencing the reuptake of serotonin
    • Red flag drug
  8. Parnate
    • Tranylcypromine MAOI (monamine oxidas inhibitor) --> increases concentrations of epinephrine, norepinephrine dopamine and serotonin through the inhibition of an enzyme
    • Anti Depressant agent
    • Red flag drug
  9. Solfoton
    • Phenobarbitol
    • Anticonvulsant and sedative hypnotic
    • Depress the sensory cortex
    • Red Flag Drug
  10. Dilantin
    • Phenytoin
    • Anticonculsant
    • Red Flag Drug
  11. NegGram
    • Nalidixic ACid
    • UTI
    • Red Flag Drug
  12. Rifadin
    • Rifampin
    • Anit-Tuberculosis
    • Inhibits the bacterial RNA synthesis by binding to the beta subunit
    • Inducer of P-Glycoprotein
    • Red Flag Drug
  13. St. Johns Wart
    • Herbal product for depression
    • Red Flag Drug
  14. Carafate
    • Sucralfate
    • Ulcers
    • Forms a protective coating that acts locally to protect the gastric lining
    • Red Flag Drug
  15. Theolair
    • Theophylline
    • Asthma Bronchodilator
    • Blocks phosphodiesterase which increases cAMP
    • red Flag Drug
  16. Cardizem
    • Diltiazem
    • Calcium channel blocker and angina pectoris
    • Substrate for P-glycoprotein
  17. Cardene
    • Nicardipine
    • Calcium channel blocker and hypertension
    • Substrate for P-glycoprotein
  18. Calan
    • Verapamil
    • Calcium Channel blocker and hypertension and angina
    • Inhibitor of P-Glycoprotein
  19. Velban
    • Vinblastine
    • Anti-neoplastice agent

    Substrate for P-Glycoprotein
  20. Oncovin
    • Vincristine
    • Anti-neoplastic agent

    Substrate for P-Glycoprotein
  21. Taxol
    • Paclitaxel
    • Anti-neoplastice agent
    • Substrate for P-Glycoprotein
  22. VePesid
    • Etoposide
    • Anti-Neoplastic Agent
    • Substrate for P-Glycoprotein
  23. Prograf
    • Tacrolimus
    • Iummunosuppressant
    • Agents used in xenograft transplantation
    • Substrate for P-Glycoprotein
  24. Decadron
    • Dexamethasone
    • Corticosteroid
    • Steroids used for infammatory
    • Substrate for P-Glycoprotein
  25. Cortef
    • Hydrocortisone
    • Corticosteroid
    • Steroids used for inflammatory conditions
    • Substrate for P-Glycoprotein
  26. Lipitor
    • Atorvastatin
    • Inhibitor of HMG-CoA reductase
    • ***CYP3A4 conversion***
  27. Zocor
    • Simvastatin
    • Inhibitor of HMG-CoA reductase
    • ***CYP3A4 conversion***
  28. Altoprev
    • Lovastatin
    • Inhibitor of HMG-CoA reductase
    • ***CYP3A4 conversion***
  29. Lescol
    • Fluvastatin
    • Inhibitor of HMG-CoA reductase
    • ^^CYP2C9^^
  30. Pravachol
    • Pravastatin
    • Inhibitor of HMG-CoA reductase
    • !!!!Metabolize by sulfation and processed by P-glycoprotein!!!!
  31. Cerivstatin
    • Inhibitor of HMG-CoA reductase
    • Metabolized primarily by CYP2C8 and to a much lesser extent by CYP3A4
  32. Erythromycin
    • An inhibitor of CYP3A4
    • Leads to increase levels of statins
    • Inhibits P-Glycoprotein
    • As well as troleandomycin and clarithromycin
  33. Azole antifungals
    • Itraconazole
    • Ketoconazole
    • Fluconazole
    • Potent inhibitor of CYP3A4
    • Fluconazole inhibits CYP2C9--> dont use Fluvastatin
    • Inhibitor of P-Glycoprotein
  34. Lamisil
    • Terbinafine
    • Possible therapuetic alternative of azole antifungals if someone is on statins
  35. Lopid
    • Gemfibrozil
    • Treatment of hypertriglyceridemia
    • Interaction mechanism appears to be additive production of myopathy and rhapdomyolysis
  36. Fenofibrate and Clofibrate
    Interaction mechanism appears to be an additive produciton of myopathy and rhabdomtolysis
  37. Sersone
    • Nefazodone
    • anitdepressant
    • One of the most potent CYP3A4 inhibitors amoung the anitdepressants
    • Myositis and rhadbdomylosis
    • Pravastatin and Fluvastatin may be reasonable alternatives
  38. Calan, Soptin, Verelan, Covera HS
    • Verapamil
    • Inhibitor of CYP3A4
  39. Grapefruit juice will not interac with:
    • Pravastatin
    • Fluvastatin
  40. S-Warfarin
    Metabolized by CYP2C9
  41. R-Warfarin
    Metabolized by CYP1A2 and CYP3A4
  42. Batrim
    • Trimethoprim/sulfamethoazole
    • Inhibits hepatic metabolism competes for protein binding sites, fever enhanced catabolism of clotting factors
    • Inhibits S-Warfarin clearance
  43. Flagyl
    • Metronidazole
    • Inhibits hepatic metabolism
    • Inhibits S-Warfarin clearance
  44. Cordarone
    • Amiodarone
    • Inhibits S-Warfarin
  45. Inhibitors of R-Warfarin
    • Cimetidine
    • Omeprazole
    • Amiodarone
    • Induction of Warfarin metabolism- leads to diminshed anti-coagulant effect
  46. Warfarin
    Decreased synthesis of normal clotting factors by inhibiting gama-carboxylation by vitamin K reductase
  47. St Johns Wort
    Herbal used to treat depression
  48. Indinavir
    • Concentrations are decreased by st johns wort
    • Substrate for P-Glycoprotein
  49. Allegra
    • Fexofenadine
    • Substrate for P-Glycoprotein
  50. Vincristine
    Substrate for P-Glycoprotein
  51. Colchcine
    Substrate for P-Glycoprotein
  52. topotecan
    Substrate for P-Glycoprotein
  53. Paclitaxel
    Substrate for P-Glycoprotein
  54. Loperamide
    Substrate for P-Glycoprotein
  55. Ritonavir
    Substrate for P-Glycoprotein
  56. Quinidine
    • Inhibits P-Glycoprotein
    • Anti-Arrthymic
  57. Azithromycin
    Inhibitor of P-Glycoprotein
  58. Valspodar
    Inhibitor of P-Glycoprotein
  59. Methotrexate
    Substrate for Organic Cation Transporter
  60. Zidovudine
    Substrate for Organic cation transporter
  61. Propenecid
    • Inhibitor of Organic Cation transporter
    • Stops antibiotics from gettting eliminated
  62. Cefadroxil Cefamandole Cefazolin
    • Inhibits Organic cation transporter
    • They block their own elimination

What would you like to do?

Home > Flashcards > Print Preview