Antihistamines

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Author:
sendzik
ID:
136426
Filename:
Antihistamines
Updated:
2012-02-20 03:22:45
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Antihistamines
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Antihistamines
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  1. 3 Basic histamine receptors
    • 1. H-1-receptor: bronchospasm
    • 2. H-2-receptor: gastric acid secretion, cutaneous vasodilation.
    • 3. H-3-receptors: inhibits neurotransmitters in the CNS.
  2. Histamine is stored and released from...
    • Mast cells
    • Basophils
    • CNS Neurons
  3. Physiologic effects of histamine release...
    • Vasodilation
    • localized reddening, edema, flare
    • Bronchoconstriction
    • Inc Chronotropy and Inotropy (heart rate & contratility)
    • Pain, itchy
    • Gastric acid secretion
  4. H1 Blockers
    Action: Block vasodilation, itching, smooth muscle stimulation.

    Uses: Prevent/Tx allergic reactions, prevent/Tx motion sickness.

    ADE: Sleepiness, confusion, fatigue, vertigo, rash, blur, diplopia.
  5. Sedating Antihistamines are contraindicated when...
    Narrow angle glaucoma, BPH, Peptic ulcer Dz, bladder obstruction.
  6. First generation Anti histamines...
    Benadryl, et al.
  7. Sencond generation Anti histamines...
    Zyrtec (Highly sedating) , et al.

    • Non-sedating:
    • Clartin, Alovert, Allegra, Clarinex
  8. H2 Blockers
    Action: Dec gastric acid secretion, dec vasodilation.

    Uses: PUD, GEARD, duodenal/gatric/stress uclers

    • ADE: HA, Diarrhea, rash, heptic and renal impairment
    • -Tagamet has worst ADE & D:D profile
    • -Pepcid is in our scope of practice
  9. How long do you wait before inserting CLs???
    -over use of topical antihistamines causes rebound vasodilation
    10 min

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