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MedChem quiz4
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antiepileptic that precipitates out of dextrose solution
phenytoin
antifungal that precipitates out of saline solution
amphotericin
what kind of pain relievers and antibiotics for precipitates?
opitates and beta-lactams
"red flag drug" that treats osteoporosis
alendronate - Fosamax
"red flag drug" that treats hyperlipidemia
cholestyramine OR colestipol
"red flag drug" that is an anticonvulsant
carbamazepine - Tegretol
"red flag drug" that treats GERD (x2)
cimetidine - Tagamet
cisapride - Propulsid
"red flag drug" that is an immunosuppressant
cyclosporin -Neoral
"red flag drug" that treats CHF
digoxin - Lanoxin
"red flag drug" that treats TB (x2)
isoniazid - Laniazid
rifampin -Rifadin
"red flag drug" that is an antifungal
itraconazole - Sporanox
"red flag drug" that treats manic-depressive illness
lithium - Eskalith
"red flag drug" class that are antibiotics
macrolides (ie. erythromycin)
quinolones (ie. nalidixic acid)
"red flag drug" that treats depression
(MAOIs)
tranylcypromine - Parnate
"red flag drug" that is an anticonvulsant and sedative hypnotic
phenobarbitol - Solfoton
"red flag drug" that is an anticonvulsant
phenytoin - Dilantin
"red flag drugS" that treat HIV/AIDS
protease inhibitors (ie. indinavir)
non-nucleoside rev. transcriptase inhibitors (ie. nevirapine)
reverse transcriptase inhibitors (ie. )
"red flag drug" class that treats UTIs
quinolones - nalidixic acid
"red flag drug" class that treats hyperlipidemia
statins (ie. atorvastatin)
"red flag HERBAL" that treats depression
St. John's wort
"red flag drug" that treats ulcers
sucralfate - Carafate
"red flag drug" that treats asthma
theophilline -Theoair
"red flag drug" that is an anticoagulant
warfarin - Coumadin
___________ is an inhibitor of p-glycoprotein often used with anticancer drugs
verapamil
name one drug and one herbal product that induces p-glycoprotein
rifampin / St.John's wort
What are some substrates for p-glycoprotein?
digoxin; fexofenadine; vincrisine; indinavir; colchicine; topotecan; paclitaxel; loperamide
what are some substrates of the organic cation transporter?
cimetidine; methotrexate; zidovudine
what are some inhibitors of the organic cation transporter?
probenecid; cefadroxil; cefamandole; cefazolin
________ is coadministered with beta-lactams in order to prevent them from being pumped out of cells
probenecid
Statins are also known as what?
HMG-CoA reductase inhibitors
Which statins use the CYP3A4 pathway?
atorvastain; simvastatin; lovastatin
What statin uses the CYP2C9 pathway?
fluvastatin
What statin is metabolized via sulfation?
pravastatin
What statin used both the CYP 2C8 and 3A4 pathways?
cerivastatin
Why is grapefruit juice a problem?
the flavinoids present in the juice inhibit both p-glycoprotein and CYP3A4
which warfarin stereoisomer uses the CYP2C9 pathway?
S-warfarin
Which warfarin stereoisomer uses both the CYP1A2 and 3A4 pathways?
R-warfarin
What is the MOA of warfarin?
decreased synthesis of normal clotting factors by inhibiting gamma-carboxylation by vitK reductase
What stereoisomer of warfarin does Bactrim inhibit?
S
What stereoisomer of warfarin does Flagyl inhibit?
S
What stereoisomer of warfarin does amiodarone inhibit?
S and R
What stereoisomer of warfarin does cimetidine inhibit?
R
What stereoisomer of warfarin does Prilosec inhibit?
R
what does cyclosporine treat?
acute transplant rejection
What 4 drugs should be avoided with warfarin?
ASA; NSAIDs: APAP; azoles
what 2 statins are okay for use with grapefruit juice?
pravastatin and fluvistatin
Author:
ffloyd
ID:
136838
Card Set:
MedChem quiz4
Updated:
2012-02-22 00:32:14
Tags:
MedChem quiz4 drug interactions statins
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Description:
MedChem quiz4 drug interactions
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