MedChem quiz4

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antiepileptic that precipitates out of dextrose solution

phenytoin
antifungal that precipitates out of saline solution

amphotericin
what kind of pain relievers and antibiotics for precipitates?

opitates and beta-lactams
"red flag drug" that treats osteoporosis

alendronate - Fosamax
"red flag drug" that treats hyperlipidemia

cholestyramine OR colestipol
"red flag drug" that is an anticonvulsant

carbamazepine - Tegretol
"red flag drug" that treats GERD (x2)
- cimetidine - Tagamet
- cisapride - Propulsid
"red flag drug" that is an immunosuppressant

cyclosporin -Neoral
"red flag drug" that treats CHF

digoxin - Lanoxin
"red flag drug" that treats TB (x2)
- isoniazid - Laniazid
- rifampin -Rifadin
"red flag drug" that is an antifungal

itraconazole - Sporanox
"red flag drug" that treats manic-depressive illness

lithium - Eskalith
"red flag drug" class that are antibiotics
- macrolides (ie. erythromycin)
- quinolones (ie. nalidixic acid)
"red flag drug" that treats depression
- (MAOIs)
- tranylcypromine - Parnate
"red flag drug" that is an anticonvulsant and sedative hypnotic

phenobarbitol - Solfoton
"red flag drug" that is an anticonvulsant

phenytoin - Dilantin
"red flag drugS" that treat HIV/AIDS
- protease inhibitors (ie. indinavir)
- non-nucleoside rev. transcriptase inhibitors (ie. nevirapine)
- reverse transcriptase inhibitors (ie. )
"red flag drug" class that treats UTIs

quinolones - nalidixic acid
"red flag drug" class that treats hyperlipidemia

statins (ie. atorvastatin)
"red flag HERBAL" that treats depression

St. John's wort
"red flag drug" that treats ulcers

sucralfate - Carafate
"red flag drug" that treats asthma

theophilline -Theoair
"red flag drug" that is an anticoagulant

warfarin - Coumadin
___________ is an inhibitor of p-glycoprotein often used with anticancer drugs

verapamil
name one drug and one herbal product that induces p-glycoprotein

rifampin / St.John's wort
What are some substrates for p-glycoprotein?

digoxin; fexofenadine; vincrisine; indinavir; colchicine; topotecan; paclitaxel; loperamide
what are some substrates of the organic cation transporter?

cimetidine; methotrexate; zidovudine
what are some inhibitors of the organic cation transporter?

probenecid; cefadroxil; cefamandole; cefazolin
________ is coadministered with beta-lactams in order to prevent them from being pumped out of cells

probenecid
Statins are also known as what?

HMG-CoA reductase inhibitors
Which statins use the CYP3A4 pathway?

atorvastain; simvastatin; lovastatin
What statin uses the CYP2C9 pathway?

fluvastatin
What statin is metabolized via sulfation?

pravastatin
What statin used both the CYP 2C8 and 3A4 pathways?

cerivastatin
Why is grapefruit juice a problem?

the flavinoids present in the juice inhibit both p-glycoprotein and CYP3A4
which warfarin stereoisomer uses the CYP2C9 pathway?

S-warfarin
Which warfarin stereoisomer uses both the CYP1A2 and 3A4 pathways?

R-warfarin
What is the MOA of warfarin?

decreased synthesis of normal clotting factors by inhibiting gamma-carboxylation by vitK reductase
What stereoisomer of warfarin does Bactrim inhibit?

S
What stereoisomer of warfarin does Flagyl inhibit?

S
What stereoisomer of warfarin does amiodarone inhibit?

S and R
What stereoisomer of warfarin does cimetidine inhibit?

R
What stereoisomer of warfarin does Prilosec inhibit?

R
what does cyclosporine treat?

acute transplant rejection
What 4 drugs should be avoided with warfarin?

ASA; NSAIDs: APAP; azoles
what 2 statins are okay for use with grapefruit juice?

pravastatin and fluvistatin

Author:	ffloyd
ID:	136838
Card Set:	MedChem quiz4
Updated:	2012-02-22 00:32:14
Tags:	MedChem quiz4 drug interactions statins
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Description:	MedChem quiz4 drug interactions
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